Seasonal variation and high multiplicity of first Plasmodium falciparum infections in children from a holoendemic area in Ghana, West Africa

Tropical Medicine & International Health : TM & IH
Robin KobbeJürgen May

Abstract

To assess the prevalence and multiplicity of Plasmodium falciparum infections in Ghanaian infants. In an epidemiological study in an area holoendemic for malaria in Ghana, the prevalence and multiplicity of P. falciparum infections (MOI) were assessed in 1069 three month-old infants by typing of the genes encoding the merozoite surface proteins 1 and 2 (msp-1, msp-2) over a recruitment period of one year. Alleles were amplified using allele family-specific polymerase chain reaction (PCR) assays and determined according to their length polymorphisms on a genetic analyzer. The occurrence of early infections was dependent on the season (month-stratified prevalence 6.4-29.0%). Diversity of msp-alleles was extensive and significantly higher in the dry than in the rainy season. The level of infection prevalence and the high multiplicity of infections (median 4, maximum 14 strains per isolate) in the first months of life indicate early contacts with parasites exhibiting a wide repertoire of antigens and, most likely, multiple infections per single mosquito bite.

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Citations

Sep 20, 2008·Current Genetics·Karen Hayton, Xin-Zhuan Su
Sep 28, 2010·BMC Infectious Diseases·Frederick N BaliraineGuiyun Yan
Oct 3, 2012·PloS One·Ingrid FelgerThomas A Smith
May 4, 2013·North American Journal of Medical Sciences·Muzamil M Abdel HamidIbrahim M El Hassan
Sep 3, 2011·Journal of Evolutionary Biology·S HuijbenA F Read
Aug 13, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Célia DechavanneFlorence Migot-Nabias
Jul 1, 2016·PLoS Computational Biology·John D O'BrienLucas Amenga-Etego
Jun 3, 2009·The Korean Journal of Parasitology·Xin-Zhuan SuRobert M Stephens
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Xin-Zhuan SuDeirdre A Joy

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