Seasonal variation in hemorrhage and focal neurologic deficit due to intracerebral cavernous malformations

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Kelly D FlemmingMichael J Link

Abstract

The objective was to determine if there was seasonal variation in the month of symptom onset in patients with intracerebral cavernous malformations (ICM). Patients seen at our institution between 1989 and 1999 with ICM identified from a radiologic database were included. Demographic data and symptoms at onset were abstracted. Symptomatic patients in this ICM database were included if the month of symptom onset was known. Comparison of proportions of patients presenting in fall and winter and during flu season were performed with the chi squared test and Fisher's exact test with significance at p<0.05. Of 292 patients identified, 179 patients had symptomatic ICM. Of these, 135 patients with symptomatic ICM were identified for whom the exact month of symptom onset was known. Eighty-seven (64.4%) presented with intracerebral hemorrhage (ICH) or focal neurologic deficit (FND) and 48 (35.6%) due to seizures. When assessing all 135 patients, 75 (55.5%) presented in the fall and winter compared to the spring and summer (p=0.1962). Eighty-three (61.4%) patients presented during flu season (p=0.0074). When assessing only those initially presenting with ICH or FND, 53 (60.9%) patients presented in the fall and winter compared to spring a...Continue Reading

References

Nov 1, 2008·Stroke; a Journal of Cerebral Circulation·Rustam Al-Shahi SalmanUNKNOWN Angioma Alliance Scientific Advisory Board
Jun 18, 2010·Current Neurology and Neuroscience Reports·Andrew J Solomon, Ruth H Whitham
Oct 12, 2010·Stroke; a Journal of Cerebral Circulation·Dean Y Li, Kevin J Whitehead
Jul 14, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Adam E HandelSreeram V Ramagopalan
Aug 30, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Lauren R HarmsJohn J McGrath
Jun 28, 2013·PloS One·Amy K KasaharaAndrew Noymer
Apr 15, 2014·Clinical Interventions in Aging·Mathias Schlögl, Michael F Holick
Oct 7, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Kishan RajMamta Bhushan Singh

❮ Previous
Next ❯

Citations

Sep 19, 2016·The International Journal of Biochemistry & Cell Biology·Saverio Francesco Retta, Angela J Glading
Oct 20, 2017·Current Cardiology Reports·Kelly D Flemming
Apr 23, 2020·Antioxidants·Hyun Ah KimSaverio Francesco Retta
Dec 31, 2020·Stroke and Vascular Neurology·Qian BaiMengzhou Xue
Oct 13, 2019·World Neurosurgery·Kelly D FlemmingGiuseppe Lanzino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cavernous Hemangioma

Cavernous hemangioma is a blood vessel defect or benign tumor that leads to leakage of blood to the surrounding tissues. This can occur in several organs including the brain, which can lead to seizures. Discover the latest research on cavernous hemangiomas here.