PMID: 9186797Jun 1, 1997Paper

Seasonal variation in postdexamethasone cortisol values in depressed inpatients. Results of least squares cosine spectral analysis

Journal of Affective Disorders
M Maes, C Schotte

Abstract

Recently, a significant seasonal variation in postdexamethasone (post-DST) cortisol values in depressed patients has been reported. This study aimed to investigate seasonal variation in post-DST cortisol values in 269 depressed patients admitted to a psychiatric ward during 70 consecutive months. By means of analysis of variance no significant differences could be detected in post-DST values in depressed men or women, alone or together, between the 12 months, the period November-February versus March-October, or between the tour quartiles. By means of spectral analysis no significant seasonal rhythms, i.e. annual or harmonic rhythms, could be found in the time series of post-DST cortisol values either in the total group of depressed patients or in depressed women separately (n = 190). Spectral analysis showed a significantly biannual rhythm in the post-DST cortisol values in depressed men, with peaks in June and December and troughs in March and September. This biannual rhythm explained 12.4% of the variance in the post-DST cortisol values of depressed men. The results show that there is a significant seasonal variation in post-DST cortisol values in depressed men, but not in depressed women.

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Citations

May 4, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Leo SherJ John Mann
Jan 28, 2003·Journal of Affective Disorders·István KecskésAnnamária Rihmer
Jul 26, 2002·Psychiatry Research·Cristina CusinEnrico Smeraldi
Jun 13, 2006·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Brian ColwellShannon Creekmur

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