Seasonal variation in stroke and stroke-associated mortality in patients with a hospital diagnosis of nonvalvular atrial fibrillation or flutter. A population-based study in Denmark

Neuroepidemiology
Lars FrostClaus Dethlefsen

Abstract

There are few data on seasonal variation in stroke and seasonal variation in mortality after stroke in patients with atrial fibrillation. We examined the seasonal pattern in stroke occurrence and the effect of the season on mortality after stroke in patients with a history of nonvalvular atrial fibrillation. We identified all individuals, aged 40-89 years, with an incident diagnosis of stroke of any nature (ischemic or hemorrhagic) in the 1980-2002 period and no history of heart valve disease and a previous or concomitant diagnosis of atrial fibrillation or flutter in the Danish National Registry of Patients. Subjects were followed in the Danish Civil Registration System for emigration and vital status. We used periodic regression models to estimate the peak-trough ratio stratified by sex, age and comorbid medical conditions. Seasonal effect on mortality after stroke was analyzed in a Cox proportional hazards model. The relative incidence of stroke estimated as the ratio of the incidence in the month of the peak (January) to the incidence in the month of the trough (July) was 1.11 (95% confidence interval: 1.07-1.15). The relative incidence of stroke was similar for men and women, did not differ by age (stratified by age 75 yea...Continue Reading

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Citations

Aug 28, 2012·BMJ Open·Anette Luther ChristensenTorben Bjerregaard Larsen
Apr 22, 2010·Neurological Research·Asterios KaragiannisVasilios G Athyros
Jun 1, 2013·North American Journal of Medical Sciences·Auda Fares
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Apr 9, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Osvaldo FustinoniUNKNOWN ReNACer Investigators
Jul 22, 2011·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Shunya TakizawaUNKNOWN Japan Standard Stroke Registry Study Group
Oct 10, 2007·Epilepsy & Behavior : E&B·Stephan RüeggChristian Schindler
Oct 12, 2017·European Journal of Public Health·Anna PoznanskaWojciech Seroka
Jun 2, 2007·Stroke; a Journal of Cerebral Circulation·Corinne HodgsonFrank Rubini
Mar 9, 2019·Environmental Geochemistry and Health·Yanbo LiMuke Zhou
Dec 21, 2018·Journal of the American Heart Association·Stacy Y ChuKevin N Sheth
Aug 31, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Mitsunori OidaTakeshi Yamashita

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