Seasonal variation in telomere dynamics in African striped mice.

Oecologia
François CriscuoloCarsten Schradin

Abstract

Telomere shortening has been used as an indicator of aging and is believed to accelerate under harsh environmental conditions. This can be attributed to the fact that telomere shortening has often been regarded as non-reversible and negatively impacting fitness. However, studies of laboratory mice indicate that they may be able to repair telomere loss to recover from environmental harshness, as indicated by recent studies in hibernating rodents. We studied seasonal variation in telomere dynamics in African striped mice (Rhabdomys pumilio) living in a highly seasonal environment. In our annual species, individuals born in the moist spring (high food availability) need to survive the harsh dry summer (low food availability) to be able to reproduce in the following spring. We studied the effect of the harsh dry vs. the benign moist season on telomere dynamics. We also tested if telomere length or the rate of change in telomere length over the dry season predicted the probablity of dissapearance from the population at the same time. Male, but not female, stripped mice showed age-related telomere erosion. Telomeres were longer at the beginning of the dry season compared to the rest of the year. Telomeres increased significantly in l...Continue Reading

References

Apr 18, 1991·Nature·E H Blackburn
May 10, 2002·Nucleic Acids Research·Richard M Cawthon
Apr 7, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Simon R W L Chan, Elizabeth H Blackburn
Jul 13, 2004·Annals of the New York Academy of Sciences·Mark F HaussmannCarol M Vleck
Dec 19, 2006·Aging Cell·Andrei SeluanovVera Gorbunova
Feb 1, 2007·Biology Letters·Alexander KotrschalDustin J Penn
May 9, 2009·Age·Vera GorbunovaAndrei Seluanov
Jun 13, 2009·Proceedings. Biological Sciences·H M SalomonsS Verhulst
Mar 31, 2010·Nature Reviews. Genetics·Anthony J Cesare, Roger R Reddel
Jul 27, 2010·FEBS Letters·Nuno M V GomesWoodring E Wright
Sep 10, 2011·Aging Cell·Emma L B Barrett, David S Richardson
Sep 17, 2011·Biology Letters·Christopher TurbillThomas Ruf
Nov 11, 2011·Proceedings. Biological Sciences·Mark F HaussmannRachel M Bowden
Jan 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Britt J HeidingerPat Monaghan
Oct 2, 2012·Cell Reports·Elsa VeraMaria A Blasco
Feb 8, 2013·Biology Letters·Christopher TurbillClaudia Bieber
Mar 21, 2013·Nature Communications·Lily DanialiAbraham Aviv
May 15, 2013·Nucleic Acids Research·Troels SteenstrupAbraham Aviv
Oct 5, 2013·Biogerontology·Mirre J P SimonsShinichi Nakagawa
May 16, 2014·PloS One·Mathilde L TissierFrançois Criscuolo
Nov 21, 2014·Proceedings. Biological Sciences·Daniel NettleMelissa Bateson
Mar 15, 2015·Biological Reviews of the Cambridge Philosophical Society·Jonathan D BlountMichael A Cant
Aug 12, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Edith GrosbelletFrançois Criscuolo
Aug 26, 2015·Ageing Research Reviews·Mirre J P Simons
Sep 9, 2015·Experimental Gerontology·Ben Dantzer, Quinn E Fletcher
Nov 3, 2015·Aging Cell·Jennifer FairlieDaniel H Nussey
Aug 19, 2016·The Journal of Experimental Biology·Franz HoelzlThomas Ruf
Dec 13, 2016·Aging Cell·Melissa Bateson, Daniel Nettle
Dec 21, 2016·The Journal of Experimental Biology·Rebecca RimbachCarsten Schradin
May 5, 2017·Biology Letters·Jelle J BoonekampSimon Verhulst
Aug 11, 2017·The Journal of Animal Ecology·Lewis G SpurginDavid S Richardson
Dec 8, 2017·Biology Letters·Sophie Reichert, Antoine Stier
Jan 18, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mats OlssonChristopher Friesen

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Software Mentioned

R package ICC
Mumin R package
multcomp R package
lme4
R
fitdistrplus
R Foundation for statistical Computing Platform
multcomp

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