Seasonal variation in the gonadotropin-releasing hormone response to kisspeptin in sheep: possible kisspeptin regulation of the kisspeptin receptor

Neuroendocrinology
Qun LiJeremy T Smith

Abstract

Kisspeptin signaling in the hypothalamus appears critical for the onset of puberty and driving the reproductive axis. In sheep, reproduction is seasonal, being activated by short days and inhibited by long days. During the non-breeding (anestrous) season, gonadotropin-releasing hormone (GnRH) and gonadotropin secretion is reduced, as is the expression of Kiss1 mRNA in the brain. Conversely, the luteinizing hormone response to kisspeptin during this time is greater. To determine whether the GnRH response to kisspeptin is increased during anestrus, we utilized hypophysial portal blood sampling. In anestrus ewes, the GnRH and LH responses to kisspeptin were greater compared to the breeding season (luteal phase). To ascertain whether this difference reflects a change in Kiss1r, we measured its expression on GnRH neurons using in situ hybridization. The level of Kiss1r was greater during the non-breeding season compared to the breeding season. To further examine the mechanism underlying this change in Kiss1r, we examined Kiss1r/GnRH expression in ovariectomized ewes (controlling for sex steroids) during the breeding and non-breeding seasons, and also ovariectomized non-breeding season ewes with or without estradiol replacement. In b...Continue Reading

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Citations

Aug 29, 2012·Reproductive Biology and Endocrinology : RB&E·Sethu SelvarajMichiya Matsuyama
Dec 12, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Julie-Ann P De Bond, Jeremy T Smith
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Apr 24, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Hiroaki OkamuraYoshihiro Wakabayashi
Mar 4, 2015·Journal of the Chinese Medical Association : JCMA·Jyun-Yuan WangChih-Hsien Chiu
Jul 22, 2015·Endocrinology and Metabolism·Holly ClarkeChanna N Jayasena
Jun 26, 2015·Journal of Animal Science and Biotechnology·Joseph A DanielJames L Sartin
Aug 14, 2012·General and Comparative Endocrinology·John P ChangAnderson O L Wong
Nov 8, 2018·The Journal of Endocrinology·Christopher J ScottBriony M McGrath
Jun 18, 2019·American Journal of Reproductive Immunology : AJRI·Christian Urias-CastroTerry M Nett
Nov 1, 2021·Biology of Reproduction·Ester Beltran-FrutosGiulia Brigante

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