Seasonal variation of gonadotropins and gonadal steroids receptors in the human pineal gland

Brain Research Bulletin
R LuboshitzkyP Lavie

Abstract

Recently abnormal melatonin secretion was demonstrated in hypogonadal male patients which was normalized during testosterone administration. These results suggested that both gonadal steroids and gonadotropins may modulate melatonin secretion, probably by activating specific receptors in the pineal gland. We used immunohistochemistry to localize luteinizing hormone, follicle stimulating hormone, estrogen and androgen receptors in human pineal glands. Tissues were obtained at autopsy from 53 adult males (aged 19-94 years) over a period of 1 year. Positive staining for the four types of receptors was evident in all 53 specimens examined. The percent of positively stained cells revealed a significant seasonal variation of gonadotropin receptors with higher values in the winter than in the summer. Day-night difference was evident only for follicle stimulating hormone-receptors during the summer and winter, with higher values at night. Androgen receptors and estrogen receptors were present in all specimens but did not reveal day-night or seasonal variations. These data demonstrate the presence of gonadotropin and gonadal steroid receptors in the human pineal gland. Gonadotropin receptors exhibited seasonal variation with higher valu...Continue Reading

References

Jan 1, 1992·The International Journal of Neuroscience·R Sandyk
May 1, 1988·The Journal of Clinical Endocrinology and Metabolism·A BrzezinskiR J Wurtman
Sep 1, 1981·European Journal of Pediatrics·F WaldhauserA Pollak
Nov 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·L J YoungD Crews
Feb 1, 1995·Journal of the Royal Army Medical Corps·P J Howorth
Feb 1, 1995·American Journal of Obstetrics and Gynecology·D L Olive
Aug 1, 1994·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P J JanssenT H Van der Kwast
Jan 1, 1993·Journal of Biological Rhythms·M A Hofman, D F Swaab
Feb 1, 1994·Physiology & Behavior·S J Scribner, K E Wynne-Edwards
Jan 1, 1996·Journal of Molecular Neuroscience : MN·R LuboshitzkyP Lavie
May 1, 1996·Journal of Pediatric Endocrinology & Metabolism : JPEM·S MantagosA Vagenakis

❮ Previous
Next ❯

Citations

Sep 5, 2001·Fertility and Sterility·R LuboshitzkyS Linn
Mar 3, 2004·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·R LuboshitzkyR Nave
Jul 5, 2006·The FEBS Journal·S R Pandi-PerumalR Hardeland
Feb 28, 2006·Journal of Pineal Research·Hugo L FideleffDaniel P Cardinali
May 23, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·R Luboshitzky, P Lavie
May 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology· VijayalaxmiTerence S Herman
Nov 1, 2021·Biology of Reproduction·Ester Beltran-FrutosGiulia Brigante

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.