PMID: 3768193Jan 1, 1986Paper

Seasonal variations in indices of bone formation precede appropriate bone mineral changes in normal men

Bone
L HyldstrupI Transbøl

Abstract

In 10 normal males aged 23-50 years measurements of serum alkaline phosphatase (s-AP) and the 24-h whole body retention of 99mTc-diphosphonate (WBR), as indices of bone formation, and the fasting urinary hydroxyproline:creatinine ratio (OHPr:Cr), as an index of bone resorption, were performed monthly from January 1983 to May 1984. Bone mineral content of the distal forearm (BMC) was measured in the middle of each quarter. From January to May BMC exhibited a reproducible, significant average increase of 2.5%, returning to baseline level between May and August. During the first quarter of both 1983 and 1984 a significant increase in s-AP and WBR was seen. Subsequently, during the second quarter of 1983, these variables fell below the mean of the year. Confirming their interrelationship, the deviations of s-AP and WBR were positively correlated throughout the study period (r = 0.51, P less than 0.05). Since the urinary OHPr:Cr ratio remained constant, the reported seasonal changes in bone mass of normal, adult males appear to result from primary changes in bone formation.

Citations

Apr 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E J BergstralhL J Melton
Dec 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E A Krall, B Dawson-Hughes
May 1, 1994·Calcified Tissue International·H RicoI Arribas
Jun 1, 1994·Calcified Tissue International·H Rico, M Revilla
Jan 1, 1991·Critical Reviews in Food Science and Nutrition·T W BouttonM P Bumsted
Dec 29, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H W WoitgeM J Seibel
Jan 27, 2004·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Paul GerdhemKarl J Obrant
Apr 4, 2008·Asian Journal of Andrology·Christer Ehrnborg, Thord Rosén
Aug 1, 1991·Calcified Tissue International·D VanderschuerenR Bouillon
Jul 3, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Christian MeierMarkus J Seibel
Feb 3, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Markus J SeibelBjoern Lemmer
Jul 12, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Aubrey BlumsohnRichard Eastell
Dec 14, 2005·Clinical Endocrinology·Christian MeierMarkus J Seibel
Aug 1, 1996·Annals of Medicine·M C BackströmR Mäki
Dec 5, 2006·The Veterinary Journal·Daniel ArensMarcus Egermann
Jan 22, 1998·The Journal of Clinical Endocrinology and Metabolism·H W WoitgeM J Seibel

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