Seasonal variations in the onset and healing rates of venous leg ulcers

Phlebology
M Simka

Abstract

As many vascular pathologies exhibit circannual fluctuation, the aim of this study was to assess the chronobiological features of venous ulcers. Based on a retrospective survey of the case histories of 391 venous ulcer patients, the rates of ulcer onset and healing in each month were analysed statistically; a time series was constructed to evaluate the seasonality. There was a significantly higher frequency of ulcer onset during the warmer part of the year (April-October), and onset showed strong seasonality. Healing rates were also unequally and statistically significantly distributed throughout the year: ulcers that appeared or that were treated with specialized treatment in the winter or summer healed slower in comparison to ulcers that began in the spring or autumn. Venous ulcers exhibit circannual fluctuations in their onset and healing rates. Hypothetically, in addition to exacerbation of chronic venous insufficiency, seasonal variations in immune system activity might potentially be responsible for this phenomenon.

References

Oct 1, 1981·The Journal of Allergy and Clinical Immunology·A Bratescu, M Teodorescu
Jun 1, 1994·Transfusion·T G Paglieroni, P V Holland
Jun 1, 1993·Journal of Interferon Research·H KatilaR Rimón
Nov 18, 1998·Annals of Neurology·K E BalashovH L Weiner
Feb 27, 1999·American Heart Journal·M PeckovaA P Hallstrom
Mar 31, 2001·The American Journal of Gastroenterology·F BoulayD Benchimol
Oct 4, 2002·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·F BiloraA Girolami
Feb 19, 2004·The American Journal of Cardiology·Paul D SteinRonald E Olson
Jun 16, 2004·Xenotransplantation·Abhilash P ChandraPhilip J O'Connell
Aug 4, 2006·The New England Journal of Medicine·John J BerganBo Eklof
Aug 25, 2006·The International Journal of Lower Extremity Wounds·Philip Coleridge Smith
Mar 6, 2007·Journal of Immunological Methods·Karin Backteman, Jan Ernerudh

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Citations

Jul 21, 2010·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·Mikel Gray
Mar 5, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·J KlodeJ Dissemond
Oct 16, 2015·Thrombosis Research·Paul FrappéHervé Décousus

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