Seasonality modifies the effect of a lipid-based nutrient supplement for pregnant rural women on birth length

The Journal of Nutrition
Laeticia C ToeLieven Huybregts

Abstract

Maternal nutritional status is a major determinant of low birth weight and fluctuates across seasons. Seasonality may influence the outcome of prenatal nutrition interventions that aim to enhance fetal growth. This study investigated seasonal modifications of the efficacy of a randomized controlled prenatal nutrition intervention trial in pregnant women to improve fetal growth in rural Burkina Faso. The second Micronutriments et Santé de la Mère et de l'Enfant study compared a lipid-based nutrient supplement (LNS) fortified with multiple micronutrients (MMNs) to an MMN supplement. Truncated Fourier series were used to characterize seasonality in birth outcomes. Models that included the Fourier series and newborn and maternal characteristics were used to assess seasonal effect modifications of prenatal supplementation on birth outcomes. Birth weight, birth length, small for gestational age as a proxy for intrauterine growth retardation, and preterm birth were significantly related to date of birth and showed important seasonal variations. LNSs, which supply energy in addition to MMNs, resulted in a significant increase in birth length (+13.5 mm, 95% CI: 6.5, 20.5 mm) at the transition from rain to dry season (September to Novemb...Continue Reading

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Citations

Jan 29, 2016·Molecular and Cellular Endocrinology·Peggy C PapathakisMark J Manary
Sep 21, 2016·BMC Medicine·Holger W UngerStephen J Rogerson
Oct 4, 2016·Maternal & Child Nutrition·William JohnsonSophie E Moore
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Sep 14, 2019·The American Journal of Tropical Medicine and Hygiene·Eita Goto
Jun 28, 2018·Reproductive Health·K Michael Hambidge, Nancy F Krebs
Sep 4, 2019·American Journal of Human Biology : the Official Journal of the Human Biology Council·Meredith W Reiches

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