Seasonality of dihydropyridine receptor binding in the heart of an anoxia-tolerant vertebrate, the crucian carp (Carassius carassius L.)

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Matti Vornanen, Vesa Paajanen

Abstract

Prolonged anoxia tolerance of facultative anaerobes is based on metabolic depression and thus on controlled reduction of energy-utilizing processes. One proposed survival mechanism is the closing of ion channels to decrease energetic cost of ion pumping (Hochachka PW. Science 231: 234-241, 1986). To test this hypothesis, the involvement of L-type Ca2+ channels in seasonal anoxia tolerance of the vertebrate heart was examined by determining the number of [methyl-3H]PN200-110 (a ligand of L-type Ca2+ channel alpha-subunit) binding sites of the cardiac tissue and the density of Ca2+ current in ventricular myocytes of an anoxia-resistant fish species, the crucian carp. In their natural environment, the fish were exposed for > 3 mo of hypoxia (O2 < 2.5 mg/l) followed by almost 8 wk of anoxia that resulted in abrupt depletion of cardiac glycogen stores in late spring. Unexpectedly, however, the number of [methyl-3H]PN200-110 binding sites did not decline in hypoxia/anoxia as predicted by the channel arrest hypothesis but remained constant for most of the year. However, in early summer, the number of [methyl-3H]PN200-110 binding sites doubled for a period of approximately 2 mo, which functionally appeared as a 74% larger Ca2+ current ...Continue Reading

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Citations

Sep 21, 2013·Fish Physiology and Biochemistry·Hanna Korajoki, Matti Vornanen
Dec 3, 2014·Physiological and Biochemical Zoology : PBZ·Jaakko HaverinenMatti Vornanen
Jul 1, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jonathan A W StecykAnthony P Farrell
Apr 17, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Jonathan A W StecykAnthony P Farrell
Mar 6, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·A P Farrell, Jonathan A W Stecyk
Oct 7, 2015·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Kerry L Kubly, Jonathan A W Stecyk
Nov 3, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Matti Vornanen, Jaakko Haverinen
Mar 24, 2015·Journal of Theoretical Biology·Petra KochováZbyněk Tonar
Mar 18, 2015·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Yang YangShi-Jian Fu
Nov 23, 2016·The Journal of Experimental Biology·Elisa TikkanenMatti Vornanen
Jul 8, 2016·The Journal of Experimental Biology·Matti Vornanen
Jun 3, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matti Vornanen, Vesa Paajanen
Jul 1, 2017·Integrative and Comparative Biology·M Denise Dearing, Kevin D Kohl
Jun 20, 2018·International Journal of Molecular Sciences·Chun Hua HuangWen Bo Liao
Sep 6, 2019·Annual Review of Marine Science·Gabriel E Machovsky-Capuska, David Raubenheimer
Jan 1, 2014·Environmental Microbiology·Kevin D KohlM Denise Dearing
Oct 15, 2013·Annals of the New York Academy of Sciences·Henry D AppelmanAndrew M Bellizzi
Mar 11, 2015·Environmental Microbiology Reports·Michaela D J BlytonDavid M Gordon
Mar 24, 2016·BMC Ecology·Jean-Jacques GodonJérôme Hamelin
Apr 20, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jonathan A W StecykMatti Vornanen
Nov 2, 2018·The Journal of Experimental Biology·Milica Mandic, Matthew D Regan
Oct 15, 2013·Molecular Ecology·Frédéric DelsucRob Knight
May 11, 2012·The Journal of Experimental Biology·Joseph J TorresM Elizabeth Clarke

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