Seasons can influence the results of the methacholine challenge test.

Annals of Thoracic Medicine
Bruno SposatoMario Naldi

Abstract

This study tried to evaluate whether a methacholine test may be influenced by the seasons. We considered 4826 consecutive subjects with normal spirometry (50.53% males; age: 35.1±16.2; forced expiratory volume in one second: 99.5±13.0%) who underwent a methacholine test for suspected asthma symptoms between 2000 and 2010. They were subdivided into four groups, like the seasons, according to the test dates. A total of 1981 (41%) resulted normal (no PD(20) was obtained with 2400 μg of methacholine); the others showed a mean LogPD(20) of 2.52±0.5 μg. The number of subjects with bronchial hyper-responsiveness (BHR) found in autumn (789, 62.3%) was higher than in summer (583, 56.7%; P=0.03). A higher number of females and overweight/obese subjects showed a BHR in autumn compared with the other seasons. The spring mean LogPD(20) value (2.48±0.48 μg) was lower if compared with the one measured in summer (2.59±0.49 μg; P=0.05). LogPD(20) value was lower in females and non-smokers in spring compared with summer (P<0.05). Overweight/obese non-smokers showed a lower LogPD(20) in spring and autumn compared with that in summer (P<0.05). Autumn was a risk factor (OR: 1.378; P=0.001) for BHR (using a PD(20) <2 400 μg as BHR limit), while spri...Continue Reading

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Citations

Jul 3, 2013·Current Medical Research and Opinion·Bruno Sposato
Jul 5, 2018·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Felipe A R MendesCelso R F Carvalho
May 21, 2014·Allergy, Asthma & Immunology Research·Bruno SposatoRaffaele Scala
Jul 11, 2013·Lung·Leon JosephShmuel Goldberg
Aug 9, 2019·Pediatric Pulmonology·Anna P TikkakoskiLauri Lehtimäki
Jun 9, 2017·Wiener klinische Wochenschrift·Slavomír PerečinskýL'ubomír Legáth

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