Seawater and freshwater challenges affect the insulin-like growth factors IGF-I and IGF-II in liver and osmoregulatory organs of the tilapia

Molecular and Cellular Endocrinology
Karl LinkElisabeth Eppler

Abstract

Contradictory studies suggest IGF-I in fish liver and gills is involved in osmoregulation, but nothing is known about the kidney and intestine's role nor about IGF-II's role in any organ. Tilapia were transferred from freshwater (FW) to seawater (SW) for 1week (wk) and retransferred to FW for another week. At 4h, 1d, 2d, 3d and 1wk after SW-transfer and FW-retransfer IGF-I, IGF-II and growth hormone receptor (GHR1) mRNA were measured by real-time PCR. Hepatic IGF-I, IGF-II and GHR1 mRNA were downregulated in parallel after SW-transfer, recovered and were again downregulated after FW-retransfer. In gills, IGF-I, IGF-II and GHR1 were upregulated synchronously after SW-transfer and, partially also after FW-retransfer. The renal genes were downregulated after SW-transfer and partially upregulated after FW-retransfer. Persisting upregulation in intestinal IGF-I mRNA occurred after FW-retransfer. Thus, endocrine and auto/paracrine IGF-I and IGF-II seem to be involved in fish osmoregulation in an organ-specific manner.

Citations

Sep 23, 2011·BMC Genetics·Joseph D NormanMoira M Ferguson
Apr 2, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Benjamin P MoormanAndre P Seale
Nov 15, 2014·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Khaled Mohammed-GebaG Martínez-Rodríguez
Jan 10, 2021·Animals : an Open Access Journal From MDPI·Matteo ZarantonielloDaniela Bertotto
May 15, 2021·Fish Physiology and Biochemistry·S ChandhiniV J Rejish Kumar

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