PMID: 8599461Oct 1, 1995Paper

Sebaceous epithelioma with sweat gland differentiation

The American Journal of Dermatopathology
C OkudaT Takenouchi

Abstract

We examined a neoplasm of > 10 years' duration on the head of a woman. Light microscopically, the neoplasm was composed of multiple epithelial lobules in the dermis. The islands were mainly made up of basaloid cells and sebaceous cells; the latter cells were focally grouped in the lobules. Neither a palisade arrangement of peripheral cells nor the formation of peritumoral clefts were seen. Ductal spaces were scattered in the lobules and their luminal surfaces showed keratinization. Furthermore, in the peripheral parts of some lobules, there were sweat-gland-like structures. Immunohistochemically, most of the lobules were shown to have stratified squamous epithelium-type keratins, while the sweat-gland-like structures were shown to have simple epithelium-type keratins and stained positive for carcinoembryonic antigen. Ultrastructurally, many cells had lipid formation in their cytoplasm, and some cells formed luminal walls keratinizing without microvilli and keratohyaline granules. Although most of this neoplasm showed sebaceous differentiation, it partially differentiated to secretory cells of sweat gland apparatus.

Citations

Feb 15, 2001·The American Journal of Dermatopathology·N Misago, Y Narisawa
Jul 23, 2008·The American Journal of Dermatopathology·Jin TanahashiShigeo Yokoyama
May 11, 2012·The American Journal of Dermatopathology·Denisa KacerovskaDmitry V Kazakov
May 23, 2012·Pathology International·Mitsuaki Ishida, Hidetoshi Okabe
Apr 4, 2017·The American Journal of Surgical Pathology·Liubov KyrpychovaDmitry V Kazakov
Feb 1, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·A Neil CrowsonMartin C Mihm
Jun 3, 1998·Journal of Cutaneous Pathology·T A NielsenA E Pellegrini
Apr 6, 2007·The Journal of Veterinary Medical Science·Koichiro KatoSusumu Tateyama
Sep 15, 2001·Applied Immunohistochemistry & Molecular Morphology : AIMM·A M HassaneinR L Spielvogel

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