Sebacic acid binding to human plasma albumin

Biochemical Pharmacology
Alessandro BertuzziA V Greco

Abstract

Sebacic (decanedioic) acid is a dicarboxylic acid proposed recently as an alternative energy substrate in total parenteral nutrition. In this paper, binding of sebacic acid to defatted human plasma albumin, also in the presence of decanoic acid, was studied by means of equilibrium dialysis. In addition, the binding of sebacic acid in human serum was investigated. Binding to defatted albumin was analysed by a model with two independent classes of sites with different affinity constants. The fitting procedure took into account some of the measurement errors that are likely to affect the equilibrium dialysis technique. We found for sebacic acid one binding site with affinity constant 3.69 x 10(4) M-1 and four to five sites with affinity constant 7.14 x 10(2) M-1. Association constants for decanoic acid are 3-4-fold larger than those of sebacic acid. Data of binding of sebacic acid in human serum suggested that only three to five of the low affinity sites are available for binding. When disodium sebacate is administered i.v. for total parenteral nutrition, a substantial fraction of sebacic anions is likely to be bound in serum.

References

Jan 1, 1978·Journal of Immunological Methods·G Koch, A Oratore
Jul 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·G MingroneM Castagneto
Jun 15, 1991·The Biochemical Journal·J H Tonsgard, S C Meredith
May 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·G MingroneE Castagneto
Dec 1, 1988·Critical Care Medicine·C WeissmanJ M Kinney
Jul 1, 1988·Biochimica Et Biophysica Acta·S BergsethJ Bremer
Nov 1, 1988·The Journal of Clinical Investigation·J H TonsgardS C Meredith
May 21, 1986·Biochimica Et Biophysica Acta·S Kølvraa, N Gregersen
Jan 1, 1984·The Journal of Trauma·G NanniR Castiglione
Aug 1, 1980·Archives of Biochemistry and Biophysics·T Osumi, T Hashimoto
Nov 1, 1982·The American Journal of Clinical Nutrition·A C Bach, V K Babayan
Aug 1, 1946·Journal of the American Chemical Society·I M KLOTZR B PIVAN

❮ Previous
Next ❯

Citations

Apr 12, 2005·Bulletin of Mathematical Biology·Susanne Ditlevsen, Andrea de Gaetano
Feb 17, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·A V GrecoF Nervi
Apr 4, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·G MingroneR Vanholder
Jan 31, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·A BertuzziR Vanholder
May 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·G MingroneM Castagneto
Jan 1, 1996·JPEN. Journal of Parenteral and Enteral Nutrition·G MingroneG Gasbarrini
Nov 1, 1995·JPEN. Journal of Parenteral and Enteral Nutrition·A BertuzziS Salinari
Jun 24, 2005·American Journal of Physiology. Endocrinology and Metabolism·Simona PanunziGeltrude Mingrone
Jun 22, 2006·American Journal of Physiology. Endocrinology and Metabolism·Serenella SalinariGeltrude Mingrone
Jan 17, 2012·British Journal of Clinical Pharmacology·Geltrude MingroneKatherine Macé
Mar 10, 1999·The American Journal of Physiology·A de GaetanoG Gasbarrini
Jun 1, 1995·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·A V Grego, G Mingrone

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.