Sec14-nodulin proteins and the patterning of phosphoinositide landmarks for developmental control of membrane morphogenesis

Molecular Biology of the Cell
Ratna GhoshVytas A Bankaitis

Abstract

Polarized membrane morphogenesis is a fundamental activity of eukaryotic cells. This process is essential for the biology of cells and tissues, and its execution demands exquisite temporal coordination of functionally diverse membrane signaling reactions with high spatial resolution. Moreover, mechanisms must exist to establish and preserve such organization in the face of randomizing forces that would diffuse it. Here we identify the conserved AtSfh1 Sec14-nodulin protein as a novel effector of phosphoinositide signaling in the extreme polarized membrane growth program exhibited by growing Arabidopsis root hairs. The data are consistent with Sec14-nodulin proteins controlling the lateral organization of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) landmarks for polarized membrane morphogenesis in plants. This patterning activity requires both the PtdIns(4,5)P2 binding and homo-oligomerization activities of the AtSfh1 nodulin domain and is an essential aspect of the polarity signaling program in root hairs. Finally, the data suggest a general principle for how the phosphoinositide signaling landscape is physically bit mapped so that eukaryotic cells are able to convert a membrane surface into a high-definition lipid-si...Continue Reading

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Citations

Mar 1, 2016·Biochimica Et Biophysica Acta·Ingo Heilmann
Mar 24, 2016·Biochimica Et Biophysica Acta·Sanja Pöyry, Ilpo Vattulainen
Mar 28, 2017·Nature Cell Biology·Yuchuan MiaoPeter N Devreotes
Jan 27, 2017·Annual Review of Plant Biology·Katharina GerthIngo Heilmann
Jun 16, 2016·Development·Ingo Heilmann
Feb 13, 2019·Journal of Cell Science·Seiya FukushimaMasahiro Ueda
Feb 11, 2016·Biochemical Society Transactions·Gerald R V Hammond
May 23, 2020·Annual Review of Plant Biology·Lise C Noack, Yvon Jaillais
Jul 19, 2017·The Journal of Biological Chemistry·Aby GrabonVytas A Bankaitis
Apr 2, 2021·Plant Physiology·Gwennogan A Dubois, Yvon Jaillais
Apr 2, 2021·Plant Physiology·Femke de Jong, Teun Munnik

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Methods Mentioned

BETA
transgenic
NMR
peptide folding
MDS
Isothermal
Gel filtration
PCR
scanning electron microscopy
confocal microscopy

Software Mentioned

OPLS
Schrödinger
MicroCal Origin
BLAST
Prime
PSI
MestReNova
AMBER99
GROMACS

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