Sec61alpha is required for dorsal closure during Drosophila embryogenesis through its regulation of Dpp signaling.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Xiaochen Wang, Robert E Ward

Abstract

During dorsal closure in Drosophila, signaling events in the dorsalmost row of epidermal cells (DME cells) direct the migration of lateral epidermal sheets towards the dorsal midline where they fuse to enclose the embryo. A Jun amino-terminal kinase (JNK) cascade in the DME cells induces the expression of Decapentaplegic (Dpp). Dpp signaling then regulates the cytoskeleton in the DME cells and amnioserosa to affect the cell shape changes necessary to complete dorsal closure. We identified a mutation in Sec61alpha that specifically perturbs dorsal closure. Sec61alpha encodes the main subunit of the translocon complex for co-translational import of proteins into the ER. JNK signaling is normal in Sec61alpha mutant embryos, but Dpp signaling is attenuated and the DME cells fail to maintain an actinomyosin cable as epithelial migration fails. Consistent with this model, dorsal closure is rescued in Sec61alpha mutant embryos by an activated form of the Dpp receptor Thick veins.

References

Jan 1, 1993·Genes & Development·P E YoungD P Kiehart
Oct 24, 1997·Science·J R Riesgo-Escovar, E Hafen
Dec 28, 1999·Annual Review of Cell and Developmental Biology·A E Johnson, M A van Waes
Apr 18, 2000·The Journal of Cell Biology·D P KiehartR A Montague
Nov 13, 2001·Developmental Cell·H JasperD Bohmann
Jul 12, 2002·Developmental Cell·Antonio JacintoPaul Martin
Jul 31, 2002·Differentiation; Research in Biological Diversity·Nicholas Harden
Jan 23, 2003·Genome Biology·Pavel TomancakGerald M Rubin
Mar 19, 2004·Current Biology : CB·Maithreyi Narasimha, Nicholas H Brown
Aug 5, 2004·Molecular Biology of the Cell·Erik L SnappMary A Lilly
Feb 16, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Monn Monn Myat
Nov 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·W Patrick DevineMark A Krasnow
Dec 22, 2005·Development·Michael B O'ConnorSeth S Blair
Oct 24, 2007·Mechanisms of Development·Beatriz García FernándezAntonio Jacinto
Sep 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Baharak ZahediNicholas Harden

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Citations

Oct 19, 2011·The Journal of Infectious Diseases·Ayaka IwasaYoshihiro Kawaoka
Jan 29, 2016·G3 : Genes - Genomes - Genetics·Ashish B ChouguleJeffrey H Thomas

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