Sec6/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant peripheral nerve sheath tumor cells

Apoptosis : an International Journal on Programmed Cell Death
Toshiaki TanakaMitsuyoshi Iino

Abstract

Sec6 and Sec8, which are components of the exocyst complex, has been concerned with various roles independent of its role in secretion, such as cell migration, invadopodia formation, cytokinesis, glucose uptake, and neural development. Given the vital roles of the exocyst complex in cellular and developmental processes, the disruption of its function may be closely related to various diseases such as cancer, diabetes, and neuronal disorders. Malignant peripheral nerve sheath tumors (MPNSTs) have high malignant potential and poor prognosis because of aggressive progression and metastasis. To date, no chemotherapeutic agents have been validated for MPNSTs treatment because how MPNSTs are resistant to chemotherapeutic agents remains unknown. This study demonstrates that combination of doxorubicin and sorafenib induces apoptosis in MPNST cells through downregulation of B cell lymphoma protein 2 (Bcl-2), Bcl-2-related protein long form of Bcl-x (Bcl-xl), and myeloid cell leukemia 1 (Mcl-1). Moreover, both Sec6 and Sec8 levels decreased after treatment with doxorubicin and sorafenib and were found to be associated with Bcl-2 and Mcl-1 expressions, but not Bcl-xl. Although Sec8 was found to be involved in the regulation of both Bcl-2 ...Continue Reading

References

Apr 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C CollinM Brennan
Jun 21, 1985·Science·Y TsujimotoC M Croce
Dec 1, 1996·Neuron·S C HsuR H Scheller
Sep 12, 1998·Science·J M Adams, S Cory
Feb 26, 1999·The Journal of Biological Chemistry·B A FroeschJ C Reed
Feb 13, 2001·The Journal of Clinical Investigation·P K Epling-BurnetteT P Loughran
Jul 5, 2001·Molecular and Cellular Biology·C M EischenJ L Cleveland
Feb 22, 2002·Oncogene·Rhonda CroxtonW Douglas Cress
Apr 16, 2002·British Journal of Cancer·A J SchraderJ Lauber
May 16, 2002·Journal of Medical Genetics·D G R EvansA Moran
Nov 16, 2004·Cancer Cell·Yan M LiMien-Chie Hung
May 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert G MakiGary K Schwartz
Sep 29, 2009·The International Journal of Biochemistry & Cell Biology·Mohamed Lamkanfi, Thirumala-Devi Kanneganti
Feb 19, 2010·Nature·Rameen BeroukhimMatthew Meyerson
Sep 15, 2010·American Journal of Clinical Oncology·Vincent M MorettiChristian M Ogilvie
Nov 5, 2011·Cancer Research·Rajarshi SenguptaJoshua B Rubin
Dec 5, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Makoto EndoYoshinao Oda
Jan 16, 2014·Frontiers in Plant Science·Lukáš SynekViktor Zárský
Jan 29, 2014·The Oncologist·Mohamad FaridRobert G Maki
Feb 8, 2014·Trends in Biochemical Sciences·Tudor MoldoveanuDouglas R Green
May 9, 2014·Oncotarget·Catherine GratasFrançois M Vallette
Jun 21, 2014·Cellular Signalling·Toshiaki Tanaka, Mitsuyoshi Iino
Jan 27, 2015·Archives of Toxicology·Waseem Ahmad SiddiquiHaseeb Ahsan
Feb 24, 2015·Biochimica Et Biophysica Acta·Edgar B CepedaIsabel Fabregat
Apr 2, 2015·Biochimica Et Biophysica Acta·Cristina CorreiaScott H Kaufmann

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