Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways

Cellular Signalling
Toshiaki Tanaka, Mitsuyoshi Iino

Abstract

Cell migration is involved in numerous biological processes, including morphogenesis, wound healing and inflammatory responses, and is regulated by harmonic modulations of cellular cytoskeletal elements. The intermediate filament cytokeratin8 is one cytoskeletal element that has been implicated in cell migration. Sec8 is a component of an exocyst complex and is associated with various phenomena, such as cell migration, invadopodia formation, cytokinesis, glucose uptake and neural development. However, the relationship between Sec8 and cytokeratin8 remains to be elucidated. In this study, depleting Sec8 in HSC3 cells suppressed their migration by controlling the phosphorylation of cytokeratin8 at Ser73. This reduced cytokeratin8 phosphorylation at Ser73 is regulated by the activation of ERK and p38 mitogen-activated protein kinases (MAPK) signalling pathways via the downregulation of p21-activated kinases by p53-induced RING-H2 (Pirh2) and seven-in-absentia homologue 1 (Siah1) under conditions of Sec8 knockdown.

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Citations

Feb 20, 2016·Apoptosis : an International Journal on Programmed Cell Death·Toshiaki TanakaMitsuyoshi Iino
Aug 8, 2015·Journal of Cellular Physiology·Toshiaki Tanaka, Mitsuyoshi Iino
Jul 29, 2016·Microbiology and Molecular Biology Reviews : MMBR·András ZekeMarie A Bogoyevitch
Sep 27, 2016·Journal of Cellular Physiology·Toshiaki TanakaMitsuyoshi Iino
May 24, 2019·Frontiers in Genetics·Hongxiao JiaoWei-Dong Li
Dec 6, 2017·International Journal of Molecular Medicine·Zhengpeng YangDongbo Xue

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