Seco-terpenoids and other constituents from Elateriospermum tapos

Journal of Natural Products
Duangpen Pattamadilok, Rutt Suttisri

Abstract

Two new taraxerane triterpenes, 2,3-seco-taraxer-14-ene-2,3,28-trioic acid 2,3-dimethyl ester ( 1) and 2,3-seco-taraxer-14-ene-2,3,28-trioic acid 3-methyl ester ( 2), along with two known triterpenes, hopenol B and aleuritolic acid, and five known flavonoids, putraflavone, kaempferol, sequoiaflavone, amentoflavone, and ginkgetin, were isolated from the leaves of Elateriospermum tapos. The stem extract yielded a new cleistanthane diterpene, 2,3-seco-sonderianol ( 3), three known triterpenes, lupeol, lupeol acetate, and 3-acetylaleuritolic acid, and three known diterpenes, yucalexin B-22, yucalexin P-15, and yucalexin P-17. The structures of these compounds were established on the basis of their spectroscopic data. Compound 1 was cytotoxic against NCI-H187 and BC cell lines and also showed in vitro antimycobacterial activity against Mycobacterium tuberculosis.

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Citations

Jan 28, 2012·European Journal of Medicinal Chemistry·Abraham GarcíaGildardo Rivera
Oct 15, 2010·Phytochemistry·Ian S BlagbroughJohn R Beeching
Jun 8, 2012·Bioorganic & Medicinal Chemistry Letters·Mai EfdiMamoru Koketsu
Feb 18, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sheng YuSam Fong Yau Li
Dec 22, 2009·Natural Product Reports·Joseph D Connolly, Robert A Hill
May 6, 2020·Natural Product Reports·Aldo AlmeidaSøren Bak
Aug 14, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Muhammad AdnanZeliha Selamoglu

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