PMID: 8588862Jan 1, 1996Paper

Secoiridoids and antifungal aromatic acids from Gentiana algida

Phytochemistry
R X TanK Hostettmann

Abstract

Fractionation of an aqueous acetone extract of the whole herb of Gentiana algida gave one new [2'-(o,m-dihydroxybenzyl)sweroside] and five known secoiridoids, together with anofinic acid, fomannoxin acid, sitosterol, daucosterol, stigmasterol, oleanolic acid, orientin and gentianose. The structures were determined by spectral methods and a few chemical transformations. Anofinic acid and fomannoxin acid were found to be active against Cladosporium cucumerinum, a plant pathogenic fungus. Preliminary structure-activity studies indicated that the presence of carboxylic moieties in these acids was presumably a precondition for activity, whereas their methyl esters, inactive to the fungus, were active against the human pathogenic yeast Candida albicans. The chemotaxonomic significance of the isolates is discussed briefly.

Citations

Jul 1, 1996·Phytochemistry·R X TanK Hostettmann
Dec 13, 1997·Phytochemistry·R X Tan, L D Kong
Jan 6, 2009·Chemical & Pharmaceutical Bulletin·Yong-Dong LuoPing Li
Feb 18, 2016·Chemistry & Biodiversity·Yu PanYuan-Zhong Wang
Nov 4, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wei XuMu Yuan
Oct 28, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniil N OlennikovLarisa M Tankhaeva
Apr 1, 1998·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·E L Ghisalberti
Jul 20, 2007·Chemistry & Biodiversity·Guo-Hong LiKe-Qin Zhang
Dec 3, 2014·Bioorganic & Medicinal Chemistry Letters·Yu-jie HuangLi-jiang Xuan
Nov 12, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniil N OlennikovLeonid N Vladimirov
Sep 12, 2019·Plant Signaling & Behavior·Gerry Aplang JanaMahmoud W Yaish

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