PMID: 6161353Nov 1, 1980Paper

Second and third degree atrioventricular block with Graves' disease: a case report and review of the literature

Pacing and Clinical Electrophysiology : PACE
R H MillerW P Baker

Abstract

A previously healthy woman experienced Adams-Stokes attacks ten weeks after the initiation of antithyroid medication for Graves' disease. The patient manifested advanced atrioventricular (A-V) block requiring a temporary transvenous pacemaker. The site of heart block was localized to the A-V node by utilizing a His bundle electrogram. With control of the hyperthyroid state, normal A-V conduction was restored. Review of the literature identified twenty-five additional cases of second or third degree A-V block associated with Graves' disease, ten of whom had Adams-Stokes syncope or convulsive seizures. The A-V nodal block was reversible with cure of the primary endocrine disease. It is postulated that excessive thyroid hormone has a direct effect on the cardiac conduction system, specifically, the region of the A-V node and bundle of His. Recommendations are made regarding the recognition and management of patients at risk for developing heart block associated with Graves' disease.

References

Feb 15, 1979·The New England Journal of Medicine·S RubenfeldP O Kohler
May 11, 1968·Lancet·D G McDevittJ A Weaver
May 1, 1970·Circulation Research·M F Arnsdorf, R W Childers
Apr 1, 1972·American Heart Journal·B G GoelJ Han
Sep 18, 1971·The Medical Journal of Australia·B L ChiaL K Tan
Jan 1, 1959·British Heart Journal·G SANDLER
Nov 1, 1960·The American Journal of Cardiology·I HOFFMAN, R D LOWREY
Aug 20, 1960·JAMA : the Journal of the American Medical Association·J J BLIZZARD, J J RUPP
Oct 1, 1963·Archives of Internal Medicine·R ROSENBLUM, A J DELMAN

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Citations

Jan 12, 2010·Journal of Medical Case Reports·Suresh KrishnamoorthyJohn Creamer
Jun 19, 2014·Journal of the American Veterinary Medical Association·Lance C VisserJohn D Bonagura
Nov 23, 2005·International Journal of Cardiology·Yu-Chen KuoMing-Hsiung Hsieh
Oct 22, 2016·Journal of the American Veterinary Medical Association·Justin R SimoneGregg S Rapoport
May 6, 2017·BMJ Case Reports·Akintayo AdesokanSujeev Mathur
Jun 22, 2001·Journal of the Royal Society of Medicine·F OsmanM D Gammage

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