Second cancers in children treated with modern radiotherapy techniques

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Uwe SchneiderBeate Timmermann

Abstract

The scattered radiation from the treatment volume might be more significant for children than for adults and, as a consequence, modern radiotherapy treatment techniques such as IMRT and passive proton therapy could potentially increase the number of secondary cancers. In this report, secondary cancer risk resulting from new treatment technologies was estimated for an adult prostate patient and a child. The organ equivalent dose (OED) concept with a linear-exponential, a plateau and a linear dose-response curve was applied to dose distributions of an adult prostate patient and a child with a rhabdomyosarcoma of the prostate. Conformal radiotherapy, IMRT with 6MV photons and proton therapy were planned. OED (cancer risk) was estimated for the whole body, the rectum and the bladder. In addition, relative cumulative risk was calculated. Secondary cancer risk in the adult is not more than 15% it increased when IMRT or passive proton therapy was compared to conventional treatment planning. In the child, risk remains practically constant or was even reduced for proton therapy. The cumulative risk in the child relative to that in the adult can be as large as 10-15. By a comparison between an adult patient and a child treated for a dise...Continue Reading

References

Jun 1, 1997·International Journal of Radiation Oncology, Biology, Physics·D FollowillA Boyer
Feb 1, 2002·Radiation and Environmental Biophysics·A M KellererL Walsh
Mar 15, 2003·Nature Reviews. Cancer·Smita Bhatia, Charles Sklar
Jul 2, 2005·International Journal of Radiation Oncology, Biology, Physics·Stephen F KryIsaac I Rosen
Jul 2, 2005·International Journal of Radiation Oncology, Biology, Physics·Stephen F KryIsaac I Rosen
Apr 19, 2006·International Journal of Radiation Oncology, Biology, Physics·Eric J Hall
Aug 11, 2006·Medical Physics·Geraldine MesolorasWen C Hsi
Oct 31, 2006·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Uwe SchneiderBarbara Kaser-Hotz
Mar 14, 2007·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Jao-Perng LinChun-Chih Lin
Oct 12, 2007·Medical Physics·Andrew WroeReinhard Schulte
Dec 25, 2007·Radiation and Environmental Biophysics·Uwe Schneider, Linda Walsh
Jan 22, 2008·International Journal of Radiation Oncology, Biology, Physics·Jeremy D RubenAlistair Hunter

❮ Previous
Next ❯

Citations

Sep 18, 2013·Radiation Protection Dosimetry·Hediye AcunAhmet Bozkurt
Jul 27, 2012·Future Oncology·Jennifer GainsMark Gaze
Oct 7, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Marc D PirothMichael J Eble
Jan 6, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M UhlK Herfarth
Dec 2, 2010·JAMA : the Journal of the American Medical Association·Julia H HayesPamela M McMahon
Feb 17, 2015·Cancers·Francesco Tommasino, Marco Durante
Feb 22, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C Demoor-GoldschmidtM-A Mahé
Apr 13, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Dag Rune Olsen, Jens Overgaard
Feb 2, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tobias GauerDirk Rades
Nov 3, 2009·International Journal of Radiation Oncology, Biology, Physics·Myonggeun YoonKwan Ho Cho
Mar 24, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kyung Su KimHak Jae Kim
Jan 22, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yasser Abo-MadyanGerhard Glatting
Feb 23, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Seonkyu KimDae Hyun Kim
Feb 5, 2013·Radiation Research·Swati GirdhaniLynn Hlatky
May 24, 2015·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Anders T HansenJørgen B Petersen
Aug 18, 2009·Biochimica Et Biophysica Acta·Emmanouil FokasRita Engenhart-Cabillic
Oct 12, 2010·International Journal of Radiation Oncology, Biology, Physics·Myonggeun YoonSang Hoon Shin
Jun 26, 2010·Physics in Medicine and Biology·Ndimofor ChoforBjörn Poppe
May 20, 2011·Nature Reviews. Cancer·Wayne D Newhauser, Marco Durante
Oct 6, 2017·Physics in Medicine and Biology·H P WieserM Bangert
Jul 19, 2013·Physics in Medicine and Biology·Antje-Christin Knopf, Antony Lomax
May 15, 2009·Current Opinion in Urology·Maximilian Stehr
Feb 27, 2019·Journal of Pediatric Hematology/oncology·Amanda ScheuermannMeghen Browning
Apr 29, 2015·Annals of the ICRP·Y YonekuraUNKNOWN International Commission on Radiological Protection
Oct 29, 2020·Radiation Protection Dosimetry·Shinnosuke Matsumoto, Shunsuke Yonai
Feb 28, 2018·International Journal of Radiation Oncology, Biology, Physics·Radhe MohanJacek Capala

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Related Papers

International Journal of Radiation Oncology, Biology, Physics
Uwe SchneiderBarbara Kaser-Hotz
International Journal of Radiation Oncology, Biology, Physics
Eric J Hall
International Journal of Radiation Oncology, Biology, Physics
Uwe SchneiderBarbara Kaser-Hotz
© 2022 Meta ULC. All rights reserved