PMID: 20126595Feb 4, 2010Paper

Second degree heart block associated with QT prolongation.

Indian Pacing and Electrophysiology Journal
Berna Saylan CevikEdide Tavli

Abstract

Pseudo 2:1 AV block when sinus intervals are shorter than the ventricular refractory period has been reported with long QT syndrome (LQTS). We report the characteristics and treatment of a patient suffering from congenital LQTS with episodes of true 2:1 AV block. The pseudo 2:1 AV block relates to the extreme prolongation of ventricular refractoriness. Several histologic studies have documented abnormalities within the conduction system, including apoptosis. Because of the rare occurrence and poor prognosis of the LQTS with impaired AV conduction, international guidelines for diagnosis and treatment are needed.

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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