Second dimension column ensemble pressure tuning in comprehensive two-dimensional gas chromatography

Journal of Chromatography. a
Khan M SharifPhilip J Marriott

Abstract

A pressure tunable (PT) coupled column ensemble has been implemented for the second dimension (2D) separation in comprehensive two dimensional gas chromatography (GC×PTGC). This process requires two columns to be connected by a pressure junction, as a replacement for a single narrow bore, short column in2D. Various2D1and2D2columns may be selected to provide complementary selectivity (polarity) compared to the1D column. The tunable residence time arising from differential pressure drop in each2D column results in a tunable fractional contribution of each column in the2D separation. A sample mixture comprising different chemical classes, including alkanes and alcohols, is used to identify the feasibility and extent of selectivity tuning possible in GC×PTGC. The column length is also varied due to the imposed challenge of wraparound in the PT coupled column system as pressures are adjusted in the2D separation. Different experimental parameters, stationary phase materials and column lengths have been applied to investigate and understand the separation behaviour of the2D PT coupled column GC×GC system. Results are discussed considering analyte retention time, peak width, linear velocity and the contribution of each2D column. A spec...Continue Reading

Citations

Mar 23, 2019·Analytical Chemistry·Israel D SouzaJared L Anderson
Dec 19, 2019·Analytical Chemistry·Michelle S S AmaralPhilip John Marriott

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