Second generation anti-cyclic citrullinated peptide (anti-CCP2) antibodies can replace other anti-filaggrin antibodies and improve rheumatoid arthritis diagnosis

Scandinavian Journal of Rheumatology
S Grootenboer-MignotC Labarre

Abstract

We compared the diagnostic performance of anti-cyclic citrullinated peptide antibodies detected with second-generation enzyme immunoassay (anti-CCP2) with that of IgM-rheumatoid factor (RF), anti-perinuclear factor (APF), and anti-keratin antibodies (AKA). The sensitivity of anti-CCP2 was better than that of APF and AKA: they were detected in 25% rheumatoid arthritis (RA) patients without detectable APF or AKA. Their specificity, evaluated in other inflammatory rheumatic disease, was similar to that of APF and AKA. Despite the lower specificity, IgM-RF in combination with anti-CCP2 is interesting, as they do not completely overlap. Anti-CCP2 antibody detection seems to be a good alternative to other anti-filaggrin antibodies in the diagnosis of RA.

References

Feb 21, 2003·Annals of the Rheumatic Diseases·T PalosuoK Aho
Apr 16, 2003·Annals of the Rheumatic Diseases·J VencovskýS Růzicková

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Citations

Feb 16, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Rudolf Mierau, Ekkehard Genth
Oct 31, 2009·Arthritis and Rheumatism·Rohit AggarwalKaren H Costenbader
Nov 1, 2006·Arthritis and Rheumatism·Tineke CantaertDominique Baeten
Feb 14, 2008·Clinical Reviews in Allergy & Immunology·Nicola Bizzaro, Marilina Tampoia
Feb 28, 2019·Clinical Rheumatology·Xue-Ping WangDong-Qing Ye
Jun 4, 2011·Scientific Studies of Reading : the Official Journal of the Society for the Scientific Study of Reading·Carolyn A DentonDavid J Francis
Nov 6, 2012·Assessment for Effective Intervention : Official Journal of the Council for Educational Diagnostic Services·Tammy D TolarSharon Vaughn
Sep 29, 2005·Rheumatology·A J W ZendmanG J M Pruijn

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