Second-generation LAI are associated to favorable outcome in a cohort of incident patients diagnosed with schizophrenia

Schizophrenia Research
René Ernst NielsenRasmus W Licht

Abstract

Investigate the associations of long-acting injectable (LAI) second generation antipsychotic drugs with number of relapses, psychiatric admissions, days hospitalized, intentional self-harm events, and costs linked to hospitalizations in incident patients diagnosed with schizophrenia. A nationwide, population-based, retrospective study utilizing mirror-image models before and after initiation of LAI SGA. 10,509 patients were included as study population, with analyses being conducted on 2223 patients in a six-month period, 1383 in a 12-month period, 713 in a 24-month period. After initiation of LAI antipsychotics, patients experienced a reduction in number of relapses with an incidence rate ratio (IRR) of 0.60 for the first six months, IRR 0.64 for the first 12 months and IRR 0.64 for the first 24 months following initiation of LAI, all P < 0.001. The number of psychiatric admissions was reduced in a similar manner with respective IRR of 0.59, 0.60 and 0.64, all P < 0.001. Psychiatric bed-days were reduced with 58, 100 and 164 days for the respective periods after LAI initiation, all P < 0.001. In a Cox regression model in patients initiated on LAI, higher age at diagnosis, hazard rate ratio (HR) 0.99, 95%CI(0.98-0.99), P < 0.00...Continue Reading

Citations

Mar 6, 2019·Journal of Psychosocial Nursing and Mental Health Services·Barbara J Limandri
Jun 7, 2019·Current Opinion in Psychiatry·Ivona Šimunović FilipčićIgor Filipčić
Jul 9, 2020·Current Opinion in Psychiatry·Ivona Šimunović FilipčićIgor Filipčić
Nov 1, 2020·Nature Reviews. Cardiology·René Ernst NielsenSvend Eggert Jensen

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