Second-line pazopanib in patients with relapsed and refractory small-cell lung cancer: a multicentre phase II study of the Hellenic Oncology Research Group

British Journal of Cancer
F KoinisA Kotsakis

Abstract

Pazopanib is a tyrosine kinase inhibitor with antiangiogenic activity. Vascular endothelial growth factor expression is increased in SCLC and is correlated with poor prognosis. The efficacy and tolerance of second-line pazopanib in SCLC was evaluated. Patients with platinum-sensitive (cohort A; n=39) and -resistant/refractory (cohort B; n=19) SCLC were enrolled in a multicentre phase II study. The primary end point was the progression-free survival rate (PFS-R) at week 8 in each cohort. Pazopanib (800 mg per day per os) was administered until progressive disease (PD). Circulating tumour cells (CTCs) were enumerated using the Cellsearch assay. All patients were evaluable for response and toxicity. In the intention-to-treat analysis, eight (13.8%) patients achieved partial response (PR) (95% confidence interval (CI): 5.0-22.7), 20 (34.5%) stable disease (SD) and 30 (51.7%) PD. Accrual in cohort B was halted because the hard-stop rule was met; in cohort A, the PFS-R was 59% (95% CI: 43.5-74.4; PR=7, SD=16). Nine (23.1%) patients received pazopanib for >6 months and 3 of them for >12 months. One pazopanib cycle resulted to a significant decrease to the number of patients with ⩾5 CTCs/7.5 ml of blood (20%) compared with baseline (50...Continue Reading

References

Jan 1, 1995·Cancer·W D TravisS S Devesa
May 16, 1998·International Journal of Cancer. Journal International Du Cancer·P SalvenH Joensuu
Mar 18, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J von PawelR Gralla
Mar 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J von PawelG Ross
Mar 2, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Van GlabbekeUNKNOWN EORTC Soft Tissue and Bone Sarcoma Group
Jun 6, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Marco LucchiCarlo Alberto Angeletti
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·W Jeffrey AllardLeon W M M Terstappen
Aug 10, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G K DyA A Adjei
Apr 25, 2006·Nature Reviews. Cancer·Laura C Michaelis, Mark J Ratain
Dec 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mary E R O'BrienTheresa Crofts
Jan 24, 2007·International Journal of Radiation Oncology, Biology, Physics·Eric T ShinoharaBo Lu
May 22, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John R EckardtGraham Ross
Sep 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew M ArnoldUNKNOWN National Cancer Institute of Canada Clinical Trials Group Study BR.20
May 14, 2008·Cancer·Bjorn I GustafssonIrvin M Modlin
Dec 20, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shadia JalalUNKNOWN Hoosier Oncology Group
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Dec 23, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Athanasios G PallisVassilis Georgoulias
Aug 19, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ping ZhanYong Song
Aug 25, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shadia JalalNasser Hanna
Jan 27, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cora N SternbergRobert E Hawkins
Jun 19, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Suresh S RamalingamDavid R Gandara
Oct 1, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Barbara J GitlitzDavid R Gandara
Nov 26, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shadia JalalNasser Hanna
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
May 14, 2011·Lancet·Jan P van MeerbeeckDirk K M De Ruysscher
Mar 16, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Giannis MountziosVassilis Georgoulias
Jun 23, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Taofeek K OwonikokoSuresh S Ramalingam
Aug 24, 2013·The New England Journal of Medicine·Robert J MotzerToni K Choueiri
Mar 19, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Miyako SatouchiNagahiro Saijo
Apr 2, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernard EscudierDavid Cella
Nov 12, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joachim von PawelMarkus F Renschler
Mar 4, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neal E ReadyEverett E Vokes

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Citations

Jun 13, 2018·Journal of Oncology Practice·Jun Gong, Ravi Salgia
Jun 14, 2018·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yi-Kun WangFei Li
Mar 17, 2018·Expert Review of Anticancer Therapy·Antonio RossiRaffaele Califano
Jun 20, 2019·Journal of Hematology & Oncology·Dwight H OwenKai He
Jul 16, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Birgitta I HiddingaJan P Van Meerbeeck

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