Second-line therapy for elderly patients with non-small cell lung cancer who failed previous chemotherapy is as effective as for younger patients

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Chieh-Hung WuRuery-Perng Perng

Abstract

It was found that second-line or thereafter therapies for patients with non-small cell lung cancer (NSCLC) who failed previous chemotherapy yielded a modest survival benefit. However, whether elderly patients (> or =70 years) benefit and are as suitable for salvage therapy as nonelderly patients (<70 years) are unknown. Whether epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) is more favorable than chemotherapeutic agents as a salvage therapy agent in elderly patients with NSCLC is also undetermined. We retrospectively reviewed and updated the data of our patients with NSCLC who received second-line salvage therapies, classified them into elderly and nonelderly groups, and compared the efficacy, toxicities, and survival of the patients. Four hundred sixty-one cases were reviewed. The nonelderly group had a similar response rate, control rate, and median survival time than the elderly group (p = 0.2, p = 0.9, and p = 0.5, respectively). The median progression-free time was numerically longer in the elderly than the nonelderly patients (p = 0.08). The nonelderly group had statistically insignificantly less hematologic toxicities than the elderly group, but more nausea and vomiting. In addition, the use of EGF...Continue Reading

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Citations

Mar 19, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A G PallisM O'Brien
Oct 17, 2015·Expert Review of Anticancer Therapy·Paola Claudia SaccoCesare Gridelli
Oct 13, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Anne S TsaoWaun Ki Hong
Aug 13, 2014·Tuberculosis and Respiratory Diseases·Seok Jeong LeeJung Hyun Chang
Jul 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A G PallisM O'Brien

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