PMID: 8599801Nov 1, 1996Paper

Second-look laparotomy for stage III epithelial ovarian cancer: rationale and current issues

Cancer Treatment Reviews
L MuderspachP S Conti

Abstract

During the past two decades, the initial treatment of an advanced ovarian malignancy has been generally uniform: it begins with an exploratory laparotomy surgically to remove as much tumor as possible (1) and to stage the cancer (2). For the 70% of patients classified as stages III and IV, surgery is then followed by combination chemotherapy. Although opinions differ as to the optimal regimen, the standard involves a platinum-based program (3), recently also including paclitaxel (4). A second-look laparotomy is often performed in all patients who achieve a clinical complete remission, that is the inability to detect disease by physical examination and non-invasive laboratory tests. This surgical procedure is able to detect clinical disease not apparent on computerized axial tomography (CT scan), ultrasound, magnetic resonance imaging (MRI), serum CA-125 levels or physical examination (5-7). Major questions, however, have arisen around the need for such a procedure, and whether one can justify it in terms of an improved outcome or merely as an assessment of prognosis (8-14). We shall review: (i) the technique; (ii) the rationale; (iii) the results that have been reported from its routine application; and (iv) controversial issue...Continue Reading

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Citations

Feb 14, 1998·Journal of the National Cancer Institute·B D DugganL Dubeau
Oct 12, 1999·Radiographics : a Review Publication of the Radiological Society of North America, Inc·S KawamotoE K Fishman
Sep 9, 2008·Ultrasound Quarterly·Manjiri DigheTheodore Dubinsky
Nov 13, 2003·Expert Opinion on Emerging Drugs·Franco Muggia, M Janice Lu
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mory NourianiLouis Dubeau

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