PMID: 9181236Jun 1, 1997Paper

Second-look laparotomy in advanced ovarian cancer: a critical assessment of morbidity and impact on survival

Annals of Surgical Oncology
R E HemplingM S Piver

Abstract

The routine inclusion of second-look laparotomy in the management of patients with epithelial ovarian cancer is controversial. At issue is the justification of morbidity incumbent upon surgery and the possible survival benefit of secondary cytoreduction. The rate of major complications of surgery was assessed among 100 consecutive patients with FIGO stage III or IV epithelial ovarian cancer who underwent second-look laparotomy. All patients demonstrated a complete clinical and biochemical (CA125 < 35 U/ml) response to first-line therapy. Patients were stratified based on findings at surgery. Patients in group 1 (n = 37) had a negative second-look laparotomy. Patients in group 2 (n = 35) had only microscopically appreciable disease. Patients in group 3 (n = 28) had macroscopic disease. Cytoreductive efforts aimed at resection of all macroscopic disease were carried out for patients in group 3. Thirteen patients (13%) had 15 major complications at surgery. Comparison of the complication rates for patients in groups 1, 2, and 3, of 10%, 8.5%, and 21.4%, respectively, did not achieve statistical significance (p = 0.228). The estimated 5-year survival for patients in groups 1, 2, and 3 of 63.9%, 39.8%, and 14.2%, did differ signific...Continue Reading

References

Jan 11, 1992·Gynecologic Oncology·M E PotterH M Shingleton
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Citations

Nov 17, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hua TuJihong Liu
Dec 21, 2000·Current Oncology Reports·C S Chu, S C Rubin
Jul 7, 2000·Seminars in Surgical Oncology·E A Sijmons, A P Heintz
Apr 9, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Aminata KanePhilippe Morice

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