Second-look laparotomy in the management of fallopian tube carcinoma

Acta Obstetricia Et Gynecologica Scandinavica
G CormioC Mangioni

Abstract

To evaluate the role of second-look laparotomy following platinum-based combination chemotherapy in patients with fallopian tube carcinoma. A retrospective chart review was conducted on 21 patients with tubal carcinoma who underwent second-look laparotomy following cytoreductive surgery and platinum-based combination chemotherapy. Thirteen patients (62%) were found to be free of disease at second-look operation. Neither stage nor grade were predictive of findings at second-look procedure. The absence of gross residual disease following primary surgery was the only predictor of disease-free status at second-look laparotomy (p < 0.01). With a mean follow-up of 49 months among the survivors, four (31%) of the patients with negative second-look laparotomy have had a recurrence. The median survival following a positive second-look laparotomy was 18 months (range 5-42 months). Second-look laparotomy provides useful prognostic information in patients with tubal carcinoma. The high rate of recurrent disease after negative second-look laparotomy, and the lack of an effective second-line treatment in patients with persistent disease, represent major criticisms of this procedure.

References

Feb 1, 1978·The Surgical Clinics of North America·A Sedlis
Oct 1, 1978·Pathology, Research and Practice·I Höpfel-Kreiner, G Mikuz
Apr 1, 1992·Acta Obstetricia Et Gynecologica Scandinavica·F Pettersson
Aug 11, 1991·Gynecologic Oncology·R R BarakatW J Hoskins
Dec 1, 1990·Obstetrics and Gynecology·M MorrisJ T Wharton
Dec 15, 1990·Cancer·P G RoseY Tsukada
Mar 1, 1989·Gynecologic Oncology·C R HarrisonB U Sevin
Jun 1, 1986·American Journal of Obstetrics and Gynecology·K C PodratzG D Malkasian
Nov 1, 1986·Cancer·E H McMurrayA Galakatos
Nov 1, 1986·Journal of Surgical Oncology·V GattoM Lankerani
Jan 1, 1986·Gynecologic Oncology·J M CainJ L Lewis
Oct 1, 1984·Gynecologic Oncology·G L EddyD M Gershenson
Jun 1, 1982·Gynecologic Oncology·W S RobertsP J DiSaia
Nov 1, 1981·British Journal of Obstetrics and Gynaecology·K S RajuE Wiltshaw
May 1, 1994·Obstetrical & Gynecological Survey·A J Nordin

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Citations

Mar 30, 2001·Gynecologic Oncology·A AdolphS Biem
Mar 30, 2005·Obstetrical & Gynecological Survey·T V AjithkumarO S Ashokkumar

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