Second-look operation for recurrent colorectal cancer based on carcinoembryonic antigen and imaging techniques

Diseases of the Colon and Rectum
J HidaK Okuno

Abstract

The usefulness of postoperative carcinoembryonic antigen (CEA) monitoring and improvements in imaging techniques have renewed enthusiasm for second-look operations (SLO) as the most effective treatment for recurrent colorectal cancer by reresection following early detection. The aim of our study is to evaluate the role of CEA and imaging techniques-directed SLO. Seven hundred fifty-six patients with Dukes Stages B and C, who had undergone curative resection, were monitored postoperatively using CEA and imaging techniques. An SLO was performed on any potentially resectable recurrence, and in addition, an SLO was done when a persistently rising CEA value was detected. Recurrence developed in 18.8 percent (142/756) of patients, and 90.8 percent (129/142) of the recurrences were detected within the first three years following curative resection. When comparing carcinomas of the colon with that of the rectum, the former were associated with significantly more hepatic and intraabdominal recurrences, whereas the latter had significantly more locoregional and pulmonary recurrences. Seventy-two patients underwent SLO. Of these patients, 54.2 percent (39/72) had all of their disease resected, and 1.4 percent (1/72) had no detectable dise...Continue Reading

Citations

Feb 1, 1997·Diseases of the Colon and Rectum·P A LuchaI T Khubchandani
Nov 23, 2000·Diseases of the Colon and Rectum·J S Wu, V W Fazio
Jul 20, 1999·Diseases of the Colon and Rectum·L A Carriquiry, A Piñeyro
Jan 9, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Hyun Hoon ChungSoon-Beom Kang
Oct 12, 2012·Surgery Today·Jin-Ichi Hida, Kiyotaka Okuno
Sep 27, 2000·American Journal of Surgery·C A Maxwell-ArmstrongJ H Scholefield
Jan 3, 2001·The British Journal of Surgery·W A BleekerJ T Plukker
Apr 1, 2004·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kang Hong LeeJin Cheon Kim
Dec 22, 2009·Expert Review of Medical Devices·Massimo Bellomi, Laura Lavinia Travaini
Dec 25, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Y LiangJ Yu
Jun 30, 2000·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J Kievit
Dec 15, 2015·The Cochrane Database of Systematic Reviews·Brian D NicholsonDavid Mant
Sep 28, 1998·Diseases of the Colon and Rectum·M RosenG Anthone
Aug 17, 2005·Cancer Investigation·Mitchell J Goldstein, Edith Peterson Mitchell

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