Second malignancies after treatment for Hodgkin's disease

Leukemia & Lymphoma
E VáradyS Eckhardt

Abstract

The occurrence of treatment-related second malignancy following Hodgkin's disease (HD) has now been recognized as a major problem. The purpose of this study was to review our experience with second malignancies in patients treated for Hodgkin's disease, comparing the results with the international literature data. Six hundred and sixty five patients with HD were treated in our department, between 1978 and 1996. Second neoplasm developed in 32 cases (4.8%). Seven secondary hematological malignancies were observed: four acute nonlymphocytic leukemias, two non-Hodgkin's lymphomas and one chronic myeloid leukemia. Among patients with second hematological malignancies, the mean age at diagnosis of HD was 44 years and the mean interval until the development of second malignancy was 6.1 years. Five patients received chemo- and radiotherapy and in two cases chemotherapy was used. Three of the seven patients are alive. Twenty-five patients have had solid tumors, affecting lung (5), breast (3), colon (3), stomach (2), urinary bladder (2), head-and-neck (1), thyroid gland (1), esophagus (1), liver (1), pancreas (1), furthermore, three sarcomas and two malignant melanomas were observed. Their mean age at the diagnosis of HD was 46 years an...Continue Reading

Citations

Oct 22, 2003·Otolaryngologic Clinics of North America·Laxmeesh M Nayak, Daniel G Deschler
Dec 5, 2003·Leukemia Research·Giorgina SpecchiaVincenzo Liso
May 10, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R ShivakumarM Wetzler
Jan 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roderich E Schwarz, Roger K Strair

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