PMID: 11309438Apr 20, 2001Paper

Second malignant neoplasms in five-year survivors of childhood cancer: childhood cancer survivor study

Journal of the National Cancer Institute
Joseph NegliaLeslie L Robison

Abstract

Because survival rates among childhood cancer patients are increasing, assessing the risk of second and subsequent malignant neoplasms (SMNs) is ever more important. Using the Childhood Cancer Survivor Study cohort, we identified the risk of SMNS: A retrospective cohort of 13 581 children diagnosed with common cancers before age 21 years and surviving at least 5 years was constructed with the use of data from patients treated at 25 U.S. and Canadian institutions. SMNs were ascertained through self-administered questionnaires and verified by pathology reports. Information on therapeutic exposures was abstracted from medical records. The risk of SMN was evaluated by standardized incidence ratios (SIRs) and excess absolute risk. Poisson multiple regression models were used to assess the impact of host and therapy factors on the risk of developing SMNS: All statistical tests were two-sided. In 298 individuals, 314 SMNs were identified (SIR = 6.38; 95% confidence interval [CI] = 5.69 to 7.13). The largest observed excess SMNs were bone and breast cancers (SIR = 19.14 [95% CI = 12.72 to 27.67] and SIR = 16.18 [95% CI = 12.35 to 20.83], respectively). A statistically significant excess of SMNs followed all childhood cancers. In multiv...Continue Reading

References

Sep 1, 1992·CA: a Cancer Journal for Clinicians·C A DeLaat, B C Lampkin
Nov 7, 1991·The New England Journal of Medicine·J P NegliaG D Hammond
Dec 12, 1991·The New England Journal of Medicine·C H PuiJ T Sandlund
Nov 1, 1990·CA: a Cancer Journal for Clinicians·W A Bleyer
Apr 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A T MeadowsS G Sallan
Sep 3, 1987·The New England Journal of Medicine·M A TuckerW Newton
Sep 1, 1987·British Journal of Cancer·J E KingstonL M Kinnier Wilson
Sep 20, 1984·The New England Journal of Medicine·J Farwell, J T Flannery
May 17, 1995·Journal of the National Cancer Institute·J F BoivinP Mauch
Aug 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N E BreslowD M Green
Jan 6, 1993·Journal of the National Cancer Institute·S L HancockR T Hoppe
Feb 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R HeynH M Maurer
May 15, 1993·Cancer·J P Neglia, M E Nesbit
Mar 21, 1996·The New England Journal of Medicine·S BhatiaA T Meadows
Apr 6, 1996·BMJ : British Medical Journal·L L Robison
Feb 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S L WoldenS S Donaldson
Feb 4, 1999·The New England Journal of Medicine·L B TravisM Stovall
Mar 18, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A SmithD Vena
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F E van LeeuwenB M Aleman
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A J SwerdlowD C Linch

❮ Previous
Next ❯

Citations

Mar 11, 2009·Archives of Internal Medicine·Cheryl L CoxLeslie L Robison
Dec 20, 2002·Cancer·Mary S WolffValerie P Wilson
Jun 28, 2012·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·P Kaatsch, D Grabow
Nov 21, 2007·Pediatric Radiology·Sue C KasteHelen Jenkinson
Mar 30, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Andrew J HopeJoseph R Simpson
Jul 28, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yavuz KoksalM Erkan Ustun
Nov 13, 2009·Acta Neuropathologica·Elżbieta CiaraKrystyna H Chrzanowska
Jan 16, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Nicolas X von der Weid
Feb 7, 2008·Journal of Mammary Gland Biology and Neoplasia·Jo K PerryPeter E Lobie
Feb 9, 2013·Journal of Neuro-oncology·Kyle StrodtbeckJill Barnholtz-Sloan
Apr 1, 2011·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Brad J Zebrack, Wendy Landier
Nov 5, 2009·Journal of General Internal Medicine·Susan HongPamela Ganschow
Jul 24, 2008·Journal of Cancer Survivorship : Research and Practice·Christine EiserUNKNOWN Late Effects Group, Sheffield (LEGS)
Mar 26, 2008·Current Treatment Options in Oncology·Daniel A MulrooneyMelissa M Hudson
Sep 18, 2013·Current Osteoporosis Reports·Carmen L Wilson, Kirsten K Ness
Feb 26, 2009·Current Urology Reports·Margarett ShnorhavorianMartin A Koyle
Jul 27, 2007·Cardiovascular Toxicology·Rebecca E Scully, Steven E Lipshultz
Jun 26, 2010·International Journal of Hematology·Yasushi IshidaKeizo Horibe
Feb 10, 2012·International Journal of Hematology·Junfa ChenYuhong Zhou
Jun 9, 2005·Hematology/oncology Clinics of North America·Richard Carvajal, Paul Meyers
Jul 3, 2013·International Journal of Pediatric Otorhinolaryngology·Brianne Barnett RobyJames D Sidman
Sep 20, 2005·International Journal of Radiation Oncology, Biology, Physics·Catherine T LeeAlfred R Smith
Mar 26, 2004·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Theresa B HaddyGregory H Reaman
Mar 21, 2013·Journal of Pediatric Urology·Sarah MariettiNicholas Holmes
Jun 1, 2005·The Medical Clinics of North America·Christopher M Masi, Olufunmilayo I Olopade
Feb 28, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·W Stites WhatleyBaskar Rao
Apr 25, 2003·Lancet·Jørgen H Olsen, Jeanette Falck Winther
May 16, 2003·Current Problems in Cancer·Anna T Meadows
Jul 12, 2003·Current Problems in Cancer·Brad J Zebrack, Lonnie K Zeltzer
May 16, 2003·Current Problems in Cancer·Daniel M Green
May 16, 2003·Current Problems in Cancer·Kevin C Oeffinger
Oct 16, 2002·International Journal of Radiation Oncology, Biology, Physics·Raymond MiralbellUwe Schneider
Mar 26, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G KleinP Kaatsch
Oct 15, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S GuérinF de Vathaire
Jul 10, 2003·Blood Cells, Molecules & Diseases·Smita Bhatia
Mar 18, 2004·Breast Cancer Research and Treatment·Yvonne Marie Coyle
Nov 3, 2005·Nature Clinical Practice. Oncology·Mike M Hawkins
Nov 3, 2005·Nature Clinical Practice. Oncology·Smita Bhatia
Mar 15, 2003·Nature Reviews. Cancer·Smita Bhatia, Charles Sklar
Oct 13, 2006·The New England Journal of Medicine·Kevin C OeffingerUNKNOWN Childhood Cancer Survivor Study

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.