PMID: 3755282Jun 1, 1986Paper

Second neoplasms after adjuvant chemotherapy for operable breast cancer

American Journal of Clinical Oncology
M K HerringG R Blumenschein

Abstract

Between 1974 and 1982, 797 patients who had operable breast cancer were treated at the University of Texas M.D. Anderson Hospital and Tumor Institute at Houston with three adjuvant chemotherapy trials consisting of fluorouracil, doxorubicin, and cyclophosphamide (FAC). The incidence of second primary malignant tumors in this group of patients was evaluated and compared with that in a historical control group of patients who had stages II and III disease (n = 186) and who did not receive adjuvant chemotherapy following surgery. Radiotherapy was given to 54% (n = 433) of the chemotherapy-treated patients and to 96% (n = 178) of the controls. The median age of the patients was 49.6 and 55 years for the treated and control groups, respectively. Second neoplasms developed in 10 chemotherapy-treated patients and in nine control patients; rates at 5 years from initiation of therapy based on actuarial curves were 1.9 and 5.0%, respectively. These second tumors developed after a median latency period of 17.5 months for the FAC-treated group and 13 months for the controls. Two cases of leukemia developed in each of the two treatment groups. The rate of second malignancy in the chemotherapy-treated patients was not increased compared with...Continue Reading

Citations

Oct 13, 2001·International Journal of Radiation Oncology, Biology, Physics·B FowbleP Anderson
Mar 10, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L A DawsonP E Goss
Dec 26, 2002·Breast Cancer Research and Treatment·Carole RubinoMonique Le
Jul 5, 1992·The New England Journal of Medicine·R E CurtisR N Hoover
Jun 30, 2001·The New England Journal of Medicine·C L Shapiro, A Recht
Jan 1, 1993·Cancer Biotherapy·M R Chasen, G Falkson
Feb 12, 2013·Journal of Radiation Research·Konstantinas Povilas ValuckasValerijus Ostapenko
Jul 1, 2005·Women's Health·Alessandra Balduzzi, Monica Castiglione-Gertsch
Dec 10, 2003·Seminars in Oncology·Sister Mary Andrew Matesich, Charles L Shapiro

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