Second-order moments of segregating sites under variable population size

Genetics
Daniel Živković, Thomas Wiehe

Abstract

The identification of genomic regions that have been exposed to positive selection is a major challenge in population genetics. Since selective sweeps are expected to occur during environmental changes or when populations are colonizing a new habitat, statistical tests constructed on the assumption of constant population size are biased by the co-occurrence of population size changes and selection. To delimit this problem and gain better insights into demographic factors, theoretical results regarding the second-order moments of segregating sites, such as the variance of segregating sites, have been derived. Driven by emerging genomewide surveys, which allow the estimation of demographic parameters, a generalized version of Tajima's D has been derived that takes into account a previously estimated demographic scenario to test single loci for traces of selection against the null hypothesis of neutral evolution under variable population size.

References

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Citations

Dec 26, 2008·Briefings in Bioinformatics·Yuseob Kim, Thomas Wiehe
Mar 24, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Wolfgang Stephan
May 23, 2013·PLoS Computational Biology·Haipeng Li, Thomas Wiehe
Jul 9, 2010·Genetics·Luca FerrettiSebastian E Ramos-Onsins
Nov 4, 2011·Genetics·E SchaperB Mehlig
Apr 18, 2009·Theoretical Population Biology·Ganeshkumar Ganapathy, Marcy K Uyenoyama
Oct 12, 2012·Molecular Ecology·Daniel Živković, Aurélien Tellier
Mar 24, 2011·Theoretical Population Biology·Daniel Živković, Wolfgang Stephan
Apr 3, 2015·Investigative Genetics·Andreas Wollstein, Wolfgang Stephan
Jun 10, 2014·Theoretical Population Biology·M RafajlovićB Mehlig
Jan 18, 2015·Theoretical Population Biology·Luca Ferretti, Sebastian E Ramos-Onsins
Oct 29, 2013·Chemical Reviews·T J Morgan, R Kandiyoti
Jul 7, 2017·Genetics·Luca FerrettiSebastian E Ramos-Onsins
Dec 21, 2019·BMC Evolutionary Biology·Daniel ŽivkovićAurélien Tellier

Related Concepts

Diploid Cell
Drosophila melanogaster
Impacts, Environmental
Genetics, Population
Underpopulation
Selection, Genetic
Variation (Genetics)
Two-Parameter Models
Arabidopsis thaliana <plant>
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