Second Periprosthetic Joint Infection Caused by Streptococcus dysgalactiae : How Genomic Sequencing Can Help Defining the Best Therapeutic Strategy

Frontiers in Medicine
Truong-Thanh PhamJacques Schrenzel

Abstract

Primary and revision arthroplasties are increasing worldwide, as are periprosthetic joint infections (PJI). The management of PJI requires surgery, the strategy of which is dictated by the acute or chronic nature of the infection, with an exchange of the implant in the event of a chronic PJI or in the case of recurrence with the same pathogen. We report the case of a 63-year-old man with two episodes of Streptococcus dysgalactiae subsp. equisimilis PJI within 9 months. Based on clinical suspicion of an haematogenous PJI, the patient was treated by DAIR (debridement, antibiotics, implant retention), while genomic sequencing revealed two different strains, confirming our hypothesis that no additional surgery was needed. Hence, we report a case where genomic analysis was decisive for the decision of the best therapeutic strategy.

References

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Oct 17, 2019·Frontiers in Medicine·Manon KolbJacques Schrenzel

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Citations

Nov 27, 2020·Frontiers in Medicine·Rossella Baldan, Parham Sendi
Dec 18, 2020·Frontiers in Cellular and Infection Microbiology·Stefano LeoJacques Schrenzel
Mar 2, 2021·Expert Review of Molecular Diagnostics·Zakareya GamieEleftherios Tsiridis
Aug 14, 2021·Expert Review of Anti-infective Therapy·Alex Van BelkumChristine C Ginocchio

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Methods Mentioned

BETA
amputation

Software Mentioned

BIGSdb

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