Second primary lymphoma or recurrence: a dilemma solved by VDJ rearrangement analysis

Leukemia & Lymphoma
Massimo LibraMauro Boiocchi

Abstract

A lymphoma patient in remission that develops a second lymphoma is frequently assumed to have had a relapse of the original lymphoma. However, the second lymphoma may instead be a new lymphoma with a different clonal origin. Comparison of histological characteristics alone is insufficient in many cases to distinguish new lymphomas from recurrent lymphomas. In contrast, clonal origins of B-cell lymphomas can be reliably compared by VDJ rearrangement analysis of B-cell IgH genes. Simultaneous lymphomas have similarly been analyzed by this technique to determine whether or not both tumors share a common clonal origin. Application of VDJ rearrangement analysis in clinical research has been important for characterizing mechanisms of lymphoma development. Furthermore, this technique has the potential to improve treatment of lymphoma patients because management of recurrent lymphomas differs from that of new lymphomas.

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Citations

Dec 31, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Shih-Sung ChuangLi-Ching Lin
Aug 26, 2009·Journal of Cutaneous Pathology·Michael G BayerlLoren E Clarke
Jan 4, 2015·International Journal of Hematology·Minoru KojimaKiyoshi Ando
Feb 6, 2016·Oncotarget·Seung Eun LeeYoung Hyeh Ko

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