Second Primary Malignancies in Patients with Well-differentiated/Dedifferentiated Liposarcoma

Anticancer Research
Eric JungWilliam W Tseng

Abstract

Well-differentiated/dedifferentiated (WD/DD) liposarcoma is a rare malignancy of putative adipocyte origin. To our knowledge, there have only been isolated case reports describing second primary cancer in patients with this disease. We report on a combined case series of such patients and explore the frequency of this occurrence using a national cancer database. Demographics and clinicopathological data were collected from patients with WD/DD liposarcoma who were found to have a concurrent or subsequent second primary cancer, at one of three sarcoma referral centers from 2014-2016. The Surveillance, Epidemiology and End Results (SEER) database was also queried to identify adult patients diagnosed with WD/DD liposarcoma between 1973-2012. Observed/expected (O/E) ratios of second primary malignancies among these cases were calculated by comparison to the age-adjusted cancer incidence in the general population using SEER*stat software. In total, 26 out of 312 consecutive patients (8.3%) with WD/DD liposarcoma at our centers had a second primary cancer identified within 2 years of liposarcoma diagnosis. In the SEER database, among 1,845 patients with WD/DD liposarcoma, 75 (4.1%) had a second cancer within 2 years after liposarcoma ...Continue Reading

Citations

Nov 22, 2019·Anti-cancer Agents in Medicinal Chemistry·Qian ZhaoBo Han
Oct 29, 2020·Clinical Orthopaedics and Related Research·Eiji NakataToshifumi Ozaki
Jul 17, 2021·Apoptosis : an International Journal on Programmed Cell Death·Chirine El-BabaNadine Darwiche

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