Second primary malignancy risk among patients with gastric cancer: a nationwide population-based study in Taiwan

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
San-Chi ChenChung-Jen Teng

Abstract

Several studies have reported an increase in second primary malignancies (SPMs) among gastric cancer patients. Patients who were newly diagnosed with gastric cancer between 1997 and 2011 were recruited from the Taiwan National Health Insurance database. Those who had antecedent malignancies or gastrointestinal stromal tumor were excluded. Standardized incidence ratios (SIRs) of SPMs were calculated. Risk factors for cancer development were analyzed by Cox proportional hazards models. Effects of treatments for gastric cancer were treated as time-dependent variables. During the 15-year study period, 47,729 gastric cancer patients were recruited. Overall, 2,110 SPMs developed during a total follow-up of 137,798 person-years. The SIR for all cancers was 1.46. The SIRs for specific follow-up periods were 1.43, 1.41, and 1.21 at >10 years, 5-10 years, and 1-5 years, respectively. After excluding SPMs that developed within 1 year, significantly higher SIRs were seen for cancers of the head and neck (1.34), esophagus (2.16), colon and rectum (1.37), bones and soft tissues (1.95), ovaries (2.89), bladder (1.47), or kidneys (1.44), as well as non-Hodgkin's lymphoma (5.56). Multivariate analysis showed that age ≥70 years [hazard ratio (HR...Continue Reading

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Citations

Jan 3, 2019·European Journal of Gastroenterology & Hepatology·Samantha MoraisNuno Lunet
Apr 19, 2018·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Samantha MoraisNuno Lunet
Oct 28, 2019·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Samantha MoraisNuno Lunet
Oct 28, 2019·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Jeong Youp Park
Feb 4, 2021·Scientific Reports·Jana HalamkovaIgor Kiss

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