Second-set rejection of mouse liver allografts is dependent on radiation-sensitive nonparenchymal cells of graft bone marrow origin

Transplantation
F FuS Qian

Abstract

Livers are accepted spontaneously when transplanted orthotopically from B10 (H2b) or BALB/c (H2d) to C3H (H2k) mice without host immunosuppression. Presensitization to donor can, however, be induced by skin grafting two weeks prior to liver transplantation, resulting in second-set or "accelerated" liver graft rejection, within 4-5 days. In this study, the role of liver nonparenchymal cells (NPC) in second-set rejection was tested by donor whole-body irradiation and replacement of donor B10 liver NPC with those of either third-party (BALB/c) or recipient strain (C3H) bone marrow. Irradiation alone (9.5 Gy) of normal B10 donors before liver transplantation significantly prolonged graft survival in presensitized C3H recipients. Three months after bone marrow transplantation (BMT), chimeric livers expressing third-party or recipient haplotype, were transplanted orthotopically into unmodified C3H recipients. Graft survival was prolonged significantly compared with livers from normal or syngeneically reconstituted B10 donors. Prolonged survival of chimeric (BALB/c->B10) livers was also evident in C3H mice presensitized to alloantigens expressed on both the liver parenchymal (B10) and third-party NPC (BALB/c) by simultaneous grafting ...Continue Reading

References

Sep 1, 1991·Transplantation·S G QianT E Starzl
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D L FaustmanP E Lacy
Apr 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S QianT E Starzl
Oct 3, 1953·Nature·R E BILLINGHAMP B MEDAWAR

❮ Previous
Next ❯

Citations

Nov 15, 1997·World Journal of Surgery·J FungT Starzl
Nov 22, 1997·Current Opinion in Immunology·B Nikolic, M Sykes
Jun 3, 2004·The Journal of Surgical Research·Jennifer H BirsnerKenneth D Chavin
Nov 1, 2011·Journal of Hepatology·Kan NakagawaToshifumi Aoyama
Sep 29, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jordi OchandoWillem J M Mulder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.