Second to fourth digit ratio: a predictor of prostate-specific antigen level and the presence of prostate cancer

BJU International
Han JungTae Beom Kim

Abstract

To investigate the relationships between the 2nd to 4th digit ratio (digit ratio) and prostate volume, prostate-specific antigen (PSA) level, and the presence of prostate cancer. Of the men that presented with lower urinary tract symptoms (LUTS) at a single tertiary academic center, 366 men aged 40 or older with a PSA level ≤ 40 ng/mL were prospectively enrolled. Right-hand 2nd and 4th digit lengths were measured prior to the PSA determinations and transrectal ultrasonography (TRUS). Prostate volumes were measured by TRUS without information about digit length. Patients with a PSA level ≥ 3 ng/mL underwent prostate biopsy. No relationship was found between prostate volume and digit ratio [correlation coefficient (r) = -0.038, P = 0.466]. But, significant negative correlations were found between digit ratio and PSA (r = -0.140, P = 0.007). When the patients were divided into two groups (Group A: digit ratio < 0.95, n = 184; Group B: digit ratio ≥ 0.95, n = 182), Group A had a higher mean PSA level than Group B (3.26 ± 5.54 ng/mL vs 1.89 ± 2.24 ng/mL, P = 0.002) and had significantly higher risks of prostate biopsy [odds ratio (OR) = 1.75, 95% CI = 1.07-2.84] and prostate cancer (OR = 3.22, 95% CI = 1.33-7.78). Patients with a lo...Continue Reading

References

Nov 1, 1975·American Journal of Physical Anthropology·S M GarnS Stinson
Aug 1, 1988·The American Journal of Surgical Pathology·J E McNeal
Nov 1, 1996·Human Reproduction·D Scutt, J T Manning
Jan 15, 1997·Journal of the National Cancer Institute·R J HendersonO Sartor
Feb 1, 1997·Nature Genetics·D P Mortlock, J W Innis
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·E GiovannucciP W Kantoff
Nov 18, 1997·Nature·T KondoD Duboule
Apr 13, 2000·Nature·T J WilliamsS M Breedlove
Oct 29, 2000·Evolution and Human Behavior : Official Journal of the Human Behavior and Evolution Society·S J Robinson, J T Manning
Feb 22, 2001·Evolution and Human Behavior : Official Journal of the Human Behavior and Evolution Society·J T. Manning, R P. Taylor
Feb 14, 2002·American Journal of Physical Anthropology·Michael PetersPam Bryden
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L BennettWilliam D Figg
Dec 19, 2002·Hormones and Behavior·Windy M BrownS Marc Breedlove
Jul 3, 2003·Urology·Martin Voracek, John T Manning
Jan 27, 2004·American Journal of Epidemiology·Rosebud O RobertsSteven J Jacobsen
Apr 29, 2004·Early Human Development·S LutchmayaJ T Manning
Apr 9, 2005·Cancer Nursing·Nikki Peters, Katrina Armstrong
Oct 24, 2008·Journal of the National Medical Association·Daniel L HowardLouie E Ross

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Citations

Nov 14, 2012·Prostate Cancer and Prostatic Diseases·M WatersO Sartor
Dec 27, 2013·Asian Journal of Andrology·I-Nae ParkTae Beom Kim
Jan 13, 2016·Prostate Cancer and Prostatic Diseases·P H C MendesH Martelli Júnior
Aug 21, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Seiji FuruyaShogo Shimamura
Mar 30, 2011·American Journal of Human Biology : the Official Journal of the Human Biology Council·Renato Nicolás Hopp, Jacks Jorge
Dec 12, 2012·International Journal of Dermatology·Linus Ikechukwu OkekeMitchelle Wachtel
Dec 12, 2012·Early Human Development·Renato Nicolás HoppJacks Jorge
Nov 8, 2012·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Jin Kyu OhTae Beom Kim
May 6, 2016·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Patrícia Helena Costa MendesHercílio Martelli Júnior
Mar 3, 2015·The Journal of Rheumatology·Kentaro DoeYoshinari Takasaki
Dec 2, 2010·British Journal of Cancer·A A RahmanK Muir
Jan 31, 2012·American Journal of Human Biology : the Official Journal of the Human Biology Council·David J P BarkerJohan G Eriksson
Jan 29, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Laura Fusar-PoliEugenio Aguglia

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