PMID: 8942838Dec 1, 1996Paper

Second-trimester cystic hygroma: prognosis of septated and nonseptated lesions

Obstetrics and Gynecology
C G BrumfieldP Cosper

Abstract

To compare karyotypic, ultrasonographic, and prognostic features of septated cystic hygromas and nonseptated cystic hygromas in second-trimester fetuses. A computerized ultrasound data base was used to identify fetuses diagnosed with cystic hygromas at 14-22 weeks' gestation. Photographs from the initial ultrasound were reviewed retrospectively for hygroma type (septated or nonseptated) and any abnormal structural findings. Fetal karyotypes were obtained from amniotic fluid, aspiration of hygroma pouches, or fetal tissue culture. Pregnancy outcome information was obtained from hospital charts and physician office records. Ultrasound findings were then compared with fetal karyotype results and pregnancy outcome data. From 1990 to 1995, 61 fetuses with cystic hygromas were identified. Karyotypes were obtained in 55 fetuses, and pregnancy outcome was available for 59. Abnormal karyotype was present in 42 of 55 fetuses (76%). The most common chromosomal abnormality in septated hygromas was the 45,X karyotype. Trisomy 21 was the most common chromosomal abnormality in nonseptated hygromas. Compared with fetuses with nonseptated cystic hygromas, those with septated cystic hygromas were more likely to be aneuploid (33 of 39 [85%] versu...Continue Reading

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Citations

Apr 13, 2007·Archives of Gynecology and Obstetrics·Ali GedikbasiYavuz Ceylan
Aug 11, 2004·Southern Medical Journal·Mathias B Forrester, Ruth D Merz
Apr 8, 2011·World Journal of Gastroenterology : WJG·Ji Min LeeHyun Joo Choi
Feb 14, 2015·Taiwanese Journal of Obstetrics & Gynecology·Donghao LuBing Peng
May 8, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Ali GedikbasiYavuz Ceylan
Dec 15, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H A TanriverdiW Schmidt
Aug 26, 1998·Obstetrics and Gynecology Clinics of North America·S J Gross, A T Bombard
Jun 6, 2007·American Journal of Obstetrics and Gynecology·Joseph G OuzounianSharon Chan
Oct 20, 2001·American Journal of Obstetrics and Gynecology·A E DonnenfeldA N Lamb
Jul 31, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C Y SanhalG Luleci
Apr 6, 2004·Obstetrics and Gynecology Clinics of North America·Theresa L Stewart
Jul 10, 2003·Clinics in Laboratory Medicine·Alan E Donnenfeld, Allen N Lamb
Feb 23, 2012·Rare Tumors·Osman TemizkanEcmel Isik
Dec 22, 2006·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Zsanett SzigetiCsaba Papp
Jun 9, 2017·Journal of Ultrasound·Gokcen OrgulM Sinan Beksac
Jan 1, 2017·Journal of Medical Ultrasound·Yen-Ni ChenShin-Wen Chen
Oct 8, 2020·American Journal of Medical Genetics. Part a·Ariel T LevyHuda B Al-Kouatly
Sep 4, 1999·Seminars in Perinatology·P G GallagherJ R Gosche

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