Second-Trimester Maternal Serum Paraxanthine, CYP1A2 Activity, and the Risk of Severe Preeclampsia

Obstetrics and Gynecology
Kacey Y EichelbergerAlison M Stuebe

Abstract

To measure the association between second-trimester maternal caffeine intake and caffeine metabolism through the CYP1A2 system and the risk of subsequent severe preeclampsia. This was a nested case-control study of women who had undergone second-trimester screening for fetal aneuploidy and had banked serum available for analysis. The outcome of interest was severe preeclampsia, and exposures were serum paraxanthine (1,7-dimethylxanthine), measured through high-performance liquid chromatography, and CYP1A2 activity, assessed by paraxanthine/caffeine ratios. We identified 51 cases of severe preeclampsia from our population of 3,992 women (1.3%), of whom 33 had sufficient serum for analysis. These were compared with 99 healthy women. Median paraxanthine concentrations were not significantly higher in women in the control group than women in the case group (96.4 ng/mL compared with 38.0 ng/mL, P=.12), and higher serum paraxanthine was not associated with lower odds of severe preeclampsia (odds ratio [OR] 0.72, confidence interval [CI] 0.48-1.08). However, we found a significantly higher paraxanthine/caffeine ratio in women in the control group than women in the case group (0.37 compared with 0.23, P=.02) and a decreased risk of pre...Continue Reading

References

Nov 1, 1991·Clinical Pharmacology and Therapeutics·W Kalow, B K Tang
Mar 10, 1998·Annals of Epidemiology·M A KlebanoffD G Wilkins
Nov 26, 1999·The New England Journal of Medicine·M A KlebanoffD G Wilkins
Feb 15, 2000·British Journal of Clinical Pharmacology·D S Ou-YangH H Zhou
Jun 29, 2001·Epidemiology·L M GrossoM B Bracken
Dec 26, 2001·Obstetrical & Gynecological Survey·E C FurneauxS C Langley-Evans
Apr 23, 2004·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·J C KhouryB Sibai
Feb 8, 2005·American Journal of Obstetrics and Gynecology·Timothy S TracyUNKNOWN National Institute for Child Health and Human Development Network of Maternal-Fetal-Medicine Units
Jan 20, 2006·Paediatric and Perinatal Epidemiology·Sheryl L Rifas-ShimanMatthew W Gillman
Mar 9, 2006·JAMA : the Journal of the American Medical Association·Marilyn C CornelisHannia Campos
Apr 28, 2006·American Journal of Epidemiology·Laura M GrossoMichael B Bracken
Jan 29, 2008·American Journal of Obstetrics and Gynecology·Xiaoping WengDe-Kun Li
Apr 2, 2008·Epidemiology·Elizabeth W TricheMichael B Bracken
Jun 19, 2009·Epidemiology·Mark A KlebanoffRichard J Levine
Aug 20, 2010·The Journal of Clinical Endocrinology and Metabolism·Arthur M BakerAlison M Stuebe
Mar 8, 2011·American Journal of Perinatology·S Katherine LaughonJanet Catov
Jun 28, 2011·The Journal of Pediatrics·Tanja G M VrijkotteMarcel B Twickler
Mar 16, 2013·Pharmacogenetics and Genomics·Maria DobrinasChin B Eap

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Citations

Apr 6, 2019·Nutrition Research Reviews·Rachele De GiuseppeHellas Cena
Apr 5, 2020·European Journal of Nutrition·Anni LehtonenMarko Lehtonen
Jan 10, 2019·BMC Pregnancy and Childbirth·Melissa D AmoscoCynthia P Palmes-Saloma
Nov 9, 2021·JAMA Network Open·Stefanie N HinkleCuilin Zhang

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