Second trimester pregnancy termination using extra-amniotic ethacridine lactate

British Journal of Obstetrics and Gynaecology
R K BhathenaJ Guillebaud

Abstract

To investigate the efficacy of ethacridine lactate by the extra-amniotic route for second trimester pregnancy termination and its associated complications. Retrospective study of women undergoing second trimester termination, over 3 1/2 years, with extra-amniotic ethacridine alone, or extra-amniotic ethacridine supplemented later by extra-amniotic 15-methyl prostaglandin F2 alpha. Teaching hospital in Bombay. 315 consecutive women undergoing late abortions with extra-amniotic ethacridine. Demographic features were similar in the two groups. In group 1, 207 women had 150 ml of 0.1% ethacridine lactate injected slowly into the extra-amniotic space. In group 2, 108 women had the initial injection supplemented 6 h later by an extra-amniotic injection of 250 micrograms (1 ml) of 15-methyl prostaglandin F2 alpha. The occurrence of abortion following the induction procedure. The development of complications such as haemorrhage, infection, or injury to the uterus or cervix. The method was successful in 191 women (92%) in group 1 and in 106 (98%) in group 2. The median induction-abortion intervals were 35 and 19 h, respectively (Mann-Whitney U test, P less than 0.001). The corrected complication rate was less than 10% (30 women), with u...Continue Reading

References

Jul 1, 1973·American Journal of Obstetrics and Gynecology·T D KerenyiD H Sherman
May 1, 1971·American Journal of Obstetrics and Gynecology·S A NabriskiU Bodman
Jan 1, 1987·Journal of Obstetrics and Gynaecology·I T Cameron, D T Baird

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Citations

Nov 22, 2011·Reviews in Obstetrics and Gynecology·Athol Kent
Aug 19, 2000·Clinical Obstetrics and Gynecology·P S Ramsey, J Owen
Sep 17, 2008·Reproductive Health Matters·Suchitra S Dalvie
Sep 29, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Christoph BergAnnegret Geipel
Oct 20, 2006·Human Reproduction Update·S LalitkumarK Gemzell-Danielsson

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