PMID: 9170470Jun 1, 1997Paper

Second-trimester ultrasound markers for detection of trisomy 21: which markers are best?

Obstetrics and Gynecology
A M VintzileosC V Ananth

Abstract

To investigate which second-trimester ultrasound markers for aneuploidy are the most diagnostically efficient in detecting fetal trisomy 21. All second-trimester genetic sonograms performed since November 1, 1992 for women at increased risk for fetal trisomy 21 were analyzed retrospectively. Statistical analysis included descriptive statistics, the test of proportions, and univariate and multivariable logistic regression analysis using trisomy 21 as the dependent variable and ten aneuploidy ultrasound markers as independent variables. There were 581 normal fetuses, 23 with trisomy 21 and four with other chromosomal abnormalities. When one or more abnormal ultrasound markers were present, the sensitivity and false-positive rate for trisomy 21 were 87% and 13.4%, respectively. After adjusting for confounders, multivariate logistic regression analysis showed the best combination of ultrasound markers for detecting trisomy 21 to be nuchal fold thickening (relative risk [RR] 85.5; 95% confidence interval [CI] 20.4, 357.7), pyelectasis (RR 25.2; 95% CI 6.7, 95.0), and short humerus (RR 20.4; 95% CI 4.5, 92.1). The model combining these three ultrasound markers yielded a sensitivity of 87% and a false-positive rate of 6.7%. By using o...Continue Reading

Citations

Dec 11, 1999·Prenatal Diagnosis·A FarinaL Bovicelli
May 5, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Y TannirandornD Charoenvidhya
Jul 15, 1999·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Y TannirandornS Phaosavasdi
May 8, 2001·Obstetrics and Gynecology·B T PierceB C Calhoun
Jun 25, 2002·The Journal of Obstetrics and Gynaecology Research·Yuen TannirandornDhiraphongs Charoenvidhya
Jun 10, 2000·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R O Bahado-SinghM J Mahoney
Dec 16, 2000·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G R DeVore
Sep 1, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·W LeeR Romero
Apr 29, 1998·Current Opinion in Obstetrics & Gynecology·L S Chitty
May 20, 2000·The Journal of Perinatal & Neonatal Nursing·C Kubas
Mar 14, 2007·Current Opinion in Obstetrics & Gynecology·Fionnuala M Breathnach, Fergal D Malone
Sep 24, 1998·British Journal of Obstetrics and Gynaecology·M O Thompson, B Thilaganathan
Nov 24, 2007·Fetal Diagnosis and Therapy·Csaba PappZoltán Papp
May 6, 2014·Journal of Pregnancy·Mariza Rumi KataguiriAntonio Fernandes Moron
Feb 7, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·B Benacerraf
May 29, 2003·Seminars in Perinatology·Bryann Bromley, Beryl R Benacerraf
Mar 15, 2006·Seminars in Perinatology·Beryl R Benacerraf
Jan 31, 2002·Clinics in Perinatology·D A Nyberg, V L Souter
Aug 26, 1998·Obstetrics and Gynecology Clinics of North America·J A Bofill, G H Sharp
Aug 6, 2003·Radiologic Clinics of North America·Nancy E Budorick, Mary K O'Boyle
Aug 20, 2010·Prenatal Diagnosis·Katherine R GoetzingerAnthony O Odibo
Apr 16, 1998·American Journal of Obstetrics and Gynecology·O DerenR O Bahado-Singh
Sep 10, 2005·American Journal of Obstetrics and Gynecology·Claudio Coco, Philippe Jeanty
Jan 29, 2000·American Journal of Obstetrics and Gynecology·A LocatelliJ C Pezzullo
Jan 16, 2010·American Journal of Obstetrics and Gynecology·Zvi KivilevitchYaron Zalel
Nov 5, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Hamza M AlrabaiSebastian Farr
Apr 6, 2004·Obstetrics and Gynecology Clinics of North America·Theresa L Stewart
Oct 14, 2008·Qualitative Health Research·Judith L M McCoyd
Dec 23, 1999·American Journal of Medical Genetics·A DruganM I Evans
Sep 12, 2002·Prenatal Diagnosis·Beryl Benacerraf
Apr 15, 2000·American Journal of Medical Genetics·A FarinaD W Bianchi
May 1, 2002·Prenatal Diagnosis·Thomas D Shipp, Beryl R Benacerraf
Aug 11, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·Y ZalelZ Kivilevitch
Jul 11, 2008·Prenatal Diagnosis·Sophie DreuxFrançoise Muller
Jan 26, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T Y LeungT K Lau
Oct 9, 2002·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Bryann BromleyBeryl R Benacerraf
Feb 17, 2007·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Fionnuala M BreathnachFergal D Malone
Nov 19, 2003·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Greggory R DeVore, Roberto Romero
Apr 22, 2004·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Vivienne L SouterDavid A Luthy

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