PMID: 15218416Jun 26, 2004Paper

Secondary acute promyelocytic leukemia following chemotherapy for non-Hodgkin's lymphoma in a child

Journal of Pediatric Hematology/oncology
Aya OgamiShinsaku Imashuku

Abstract

Of the several kinds of therapy-related leukemia, therapy-related acute promyelocytic leukemia (t-APL) is most closely associated with topoisomerase II inhibitor administration for treatment of malignancies in adults. Although rare in children, the majority of therapy-related malignancies have been etoposide-related APL associated with Langerhans cell histiocytosis. The authors describe the development of t-APL after chemotherapy administered for non-Hodgkin's lymphoma (NHL) in an 8-year-old girl. One month after cessation of the 3-year chemotherapy regimen of doxorubicin and other agents but not etoposide or radiotherapy, the patient was diagnosed with t-APL with positive PML-RARA molecular abnormality. The patient attained a complete remission following treatment with all-trans retinoic acid-containing chemotherapy. Thereafter, she successfully received hematopoietic stem cell transplantation from an HLA-matched sibling donor. Development of t-APL associated with NHL in children appears to be rare.

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Citations

Jun 19, 2013·Medical Oncology·Armin Rashidi, Stephen I Fisher
Jun 8, 2014·Best Practice & Research. Clinical Haematology·Matthew A KutnyJames H Feusner
Aug 31, 2007·Pediatric Blood & Cancer·Peter E ZageStewart Goldman
Mar 4, 2011·Pediatric Blood & Cancer·Srividya SathiyamoorthyMetin Ozdemirli
Feb 7, 2020·Children·Shannon E Conneely, Alexandra M Stevens

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