Secondary analyses from a randomized clinical trial: age as the key prognostic factor in endometrial carcinoma

American Journal of Obstetrics and Gynecology
Pierluigi Benedetti PaniciCostantino Mangioni

Abstract

The purpose of this study was to explore in greater depth the outcomes of the Italian randomized trial investigating the role of pelvic lymphadenectomy in clinical early stage endometrial cancer. In the attempt to identify the patients with poorer prognosis, the impact of age and body mass index were also thoroughly investigated by cancer-specific survival (CSS) analyses. Survival outcomes of trial patients were analyzed in relation to age (≤65 years and >65 years) in the 2 arms (lymphadenectomy and no lymphadenectomy) and in the whole population of the trial. Univariate and multivariable analyses of CSS and overall survival (OS) of patients showed that age >65 years is a strong independent poor prognostic factor (5-y OS 92.1% and 78.4% in ≤65 years and >65 years patients, respectively, P < .0001; 5-y CSS 93.8% and 83.5% in ≤65 years and >65 years patients, respectively, P = .003). Among women ≤65 years, node negative patients had 94.4% 5-y OS and 96.3% 5-y CSS vs 74.3% 5-y OS and 74.3% 5-y CSS for node positive patients (P = .009 and P = .002, respectively), while among women >65 y, node negative patients had 75.7% 5-y OS and 83.6% 5-y CSS vs 74.1% 5-y OS and 83.3% 5-y CSS for node positive patients (P = .55 and P = .58, respe...Continue Reading

References

Feb 1, 1983·Gynecologic Oncology·J V Bokhman
Aug 29, 1996·The New England Journal of Medicine·P G Rose
Sep 28, 2000·Gynecologic Oncology·A J MundtP P Connell
Nov 25, 2003·Cancer·Kaled M AlektiarRichard R Barakat
Aug 3, 2004·Nature Reviews. Cancer·Eugenia E Calle, Rudolf Kaaks
Apr 2, 2005·American Journal of Clinical Oncology·Pauline T TruongSkaria Alexander
Oct 27, 2006·International Journal of Cancer. Journal International Du Cancer·Tone BjørgeElisabete Weiderpass
May 11, 2007·Gynecologic Oncology·Lina AlbitarKimberly K Leslie
Jan 12, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Marjorie L McCulloughEugenia E Calle
Jul 16, 2010·Cancer Causes & Control : CCC·Ashley S FelixFaina Linkov
Nov 30, 2010·Gynecologic Oncology·Nicole D FlemingChristine S Walsh
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Mar 3, 2012·American Journal of Obstetrics and Gynecology·Stefano BasilePierluigi Benedetti Panici
Sep 11, 2012·Journal of the National Cancer Institute·Anthony KongTheresa A Lawrie
Apr 16, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C M NagleUNKNOWN Australian National Endometrial Cancer Study Group
Apr 18, 2013·Cancer Epidemiology·Paige WartkoBritton Trabert

❮ Previous
Next ❯

Citations

Apr 1, 2014·Archives of Gynecology and Obstetrics·Sara Y BruckerD Wallwiener
Oct 16, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Simi SantalaMarkku Santala
May 13, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Taru TuomiMikko Loukovaara
Mar 15, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Mary McGunigalVishal Gupta
Oct 3, 2017·The Cochrane Database of Systematic Reviews·Jonathan A FrostJo Morrison
Feb 22, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Violante Di DonatoPierluigi Benedetti Panici
Oct 24, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Annukka PasanenRalf Bützow
Oct 29, 2015·Journal of Gynecologic Oncology·Giorgio BoganiFrancesco Raspagliesi
Apr 16, 2015·Journal of Gynecologic Oncology·Emmanuelle ArsènePierre Collinet
Sep 21, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Annukka PasanenMikko Loukovaara
Oct 16, 2018·Minerva ginecologica·Andrea PapadiaMichael D Mueller
Dec 24, 2019·Indian Journal of Surgical Oncology·Prerna LakhwaniKapil Kumar
Jul 8, 2018·Journal of Experimental & Clinical Cancer Research : CR·Giacomo CorradoEnrico Vizza
Feb 23, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Cinzia CrivellaroElisabetta De Bernardi
Mar 23, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Anne Maarit KolehmainenMikko Loukovaara
Jul 1, 2019·Archives of Gynecology and Obstetrics·Ling ZhaoJiali Luo
Feb 16, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Annukka PasanenRalf Bützow
Oct 1, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Annukka PasanenMikko Loukovaara
Mar 1, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Violante Di DonatoPierluigi Benedetti Panici
Sep 1, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Annukka PasanenRalf Bützow
Oct 28, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Innocenza PalaiaPierluigi Benedetti Panici
Aug 15, 2015·Clinical Case Reports·Pierre LunardiStéphanie Motton
Nov 30, 2019·Archives of Gynecology and Obstetrics·Andrea PapadiaMichael D Mueller
Oct 17, 2020·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Vito Andrea CapozziRoberto Berretta
Sep 4, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Renée L Kokts-PorietisChristine M Friedenreich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.