Secondary bladder cancer after upper tract urothelial carcinoma in the US population

BJU International
Max KatesJames M McKiernan

Abstract

Study Type - Prognosis (cohort) Level of Evidence 2a. What's known on the subject? and What does the study add? It is known that a certain percentage of patients treated for upper tract urothelial carcinoma (UTUC) will go on to develop a secondary bladder cancer; however, the risk factors for developing a secondary bladder tumour have not been studied in a population-based setting. Given the large changes in how UTUC has been diagnosed and managed in recent years, this study aimed to evaluate the natural history of UTUC in the US population over a 30-year period, with a particular emphasis on the development of secondary bladder cancer. • To assess the natural history of upper tract urothelial carcinoma (UTUC) and the development of lower tract secondary cancer. • Patients diagnosed with UTUC between 1975 and 2005 were identified within nine Surveillance, Epidemiology and End Results registries. • Baseline characteristics of patients with and without secondary bladder cancer were compared. • A multivariate logistic regression model was fitted to test if the year of diagnosis predicted the likelihood of developing a secondary bladder cancer. • Of the 5212 patients with UTUC, 242 (4.6%) had a secondary bladder cancer (range: 1.7-...Continue Reading

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Citations

Sep 17, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Giorgio GandagliaMaxine Sun
Apr 22, 2016·World Journal of Urology·Aurélie MbeutchaShahrokh F Shariat
Dec 21, 2016·Case Reports in Oncological Medicine·Azka AliLong H Dang
Jul 16, 2020·Investigative and Clinical Urology·Tao YangJinhai Fan

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